{"id":"W2098194107","doi":"10.1371/journal.ppat.1005142","title":"The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo","year":2015,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":523,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Norges Forskningsråd; Celgene","keywords":"Romidepsin; Depsipeptide; In vivo; Human immunodeficiency virus (HIV); Chemistry; Biology; Virology; Genetics; Histone deacetylase; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002815652,0.0001252077,0.0001616256,0.00006233725,0.0001561147,0.00001703303,0.0001989887,0.0001054844,0.0003017802],"category_scores_gemma":[0.0003298822,0.0000797032,0.00005655949,0.0001304899,0.0001336381,0.00005205895,0.00008136076,0.0002039421,0.007310182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008916816,"about_ca_system_score_gemma":0.0001230113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001037408,"about_ca_topic_score_gemma":0.0004187185,"domain_scores_codex":[0.9988067,0.000263589,0.0001887176,0.0002112116,0.00005773039,0.0004720539],"domain_scores_gemma":[0.999347,0.0001855206,0.00003891325,0.0003109662,0.00005965954,0.00005793065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005068949,0.000901661,0.2507743,0.00001657637,0.0004168041,0.0005908395,0.002140113,0.00001396382,0.6263795,0.0007740093,0.1115182,0.005967186],"study_design_scores_gemma":[0.01004702,0.001056219,0.06799399,0.0001646573,0.0001565318,0.0002109908,0.004295601,0.00003288846,0.2863979,0.002002371,0.626807,0.0008348839],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831412,0.003086688,0.000005868494,0.0008068681,0.0002049423,0.0003265011,0.0002084086,0.0000568385,0.01216261],"genre_scores_gemma":[0.9852287,0.0002942402,0.0001321432,0.00006234573,0.00002506326,0.00008189261,0.0000734573,0.00001547033,0.01408671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5152888,"threshold_uncertainty_score":0.9934627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03781327464066974,"score_gpt":0.2578369715086236,"score_spread":0.2200236968679539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}