{"id":"W2098218026","doi":"10.1124/mol.114.096016","title":"Potent Trypanocidal Curcumin Analogs Bearing a Monoenone Linker Motif Act on Trypanosoma brucei by Forming an Adduct with Trypanothione","year":2014,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Wellcome Trust","keywords":"Linker; Curcumin; Antiparasitic; Glutathione; Trypanosoma brucei; Biochemistry; Stereochemistry; Chemistry; In vitro; Mechanism of action; Antiparasitic agent; Trypanosoma; Adduct; Biology; Enzyme; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001032276,0.0002495048,0.0001437581,0.0000985973,0.0001080772,0.00006707945,0.0001704573,0.0002215583,0.003189499],"category_scores_gemma":[0.00007815529,0.0001069907,0.0001061903,0.00005571205,0.0001376307,0.0001502393,0.0001673293,0.0002963648,0.0004520486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001089927,"about_ca_system_score_gemma":0.0001137231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000254369,"about_ca_topic_score_gemma":0.0007279828,"domain_scores_codex":[0.9999591,0.000008376697,0.000001858702,0.000008014519,0.000006878469,0.00001571248],"domain_scores_gemma":[0.9999515,0.000009459979,0.00001300587,0.000008395636,0.000005464922,0.00001217486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002458759,0.00003221295,0.0001436329,0.00007852799,0.000009386062,0.00006946349,0.00002408301,0.0001002421,0.9958845,0.0002008134,0.0001221655,0.003089114],"study_design_scores_gemma":[0.00005668191,0.001532716,0.00175708,0.000008648899,0.0000215825,0.0001921449,0.0000191826,0.0002093209,0.9920408,0.00005092984,0.004104843,0.000006148531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877328,0.001910736,0.003534982,0.0001409945,0.0000524858,0.000100555,0.0001597126,0.0001405089,0.006227286],"genre_scores_gemma":[0.9952198,0.0006017818,0.001102754,0.00007317338,0.000007661607,0.0000257356,0.000121715,0.000006620578,0.00284068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003189499,"threshold_uncertainty_score":0.01066995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01302725786246586,"score_gpt":0.3078928356666946,"score_spread":0.2948655778042288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}