{"id":"W2098218026","doi":"10.1124/mol.114.096016","title":"Potent Trypanocidal Curcumin Analogs Bearing a Monoenone Linker Motif Act on Trypanosoma brucei by Forming an Adduct with Trypanothione","year":2014,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Wellcome Trust","keywords":"Linker; Curcumin; Antiparasitic; Glutathione; Trypanosoma brucei; Biochemistry; Stereochemistry; Chemistry; In vitro; Mechanism of action; Antiparasitic agent; Trypanosoma; Adduct; Biology; Enzyme; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006345592,0.0004820735,0.0006754752,0.0003988537,0.0003241532,0.00007050238,0.0004192172,0.0002808598,0.0004644675],"category_scores_gemma":[0.0001353974,0.0004147794,0.0001988939,0.0005784985,0.0002818471,0.0002278474,0.0001270912,0.0009334347,0.0001645311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002615358,"about_ca_system_score_gemma":0.0002596115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001384528,"about_ca_topic_score_gemma":0.00001473815,"domain_scores_codex":[0.9962785,0.0003155316,0.0005132168,0.0009548612,0.0007068001,0.001231112],"domain_scores_gemma":[0.9977198,0.0001325825,0.0001815961,0.0007880076,0.000239921,0.0009381228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009163775,0.0009160405,0.000405473,0.00005051168,0.0003238865,0.000190411,0.000158949,0.0001186838,0.9616149,0.0003900786,0.00477874,0.03013597],"study_design_scores_gemma":[0.01103948,0.006916858,0.0683758,0.0000799042,0.0004458119,0.0007250327,0.0001597353,0.005142253,0.8495468,0.0001636413,0.05663686,0.0007678172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703313,0.000247071,0.01737362,0.005128541,0.0001783496,0.001147579,0.0000541843,0.0002362961,0.005303117],"genre_scores_gemma":[0.9909862,0.0000464995,0.002269515,0.004699933,0.0004036383,0.0002487829,0.000293167,0.0001264038,0.0009258694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1120681,"threshold_uncertainty_score":0.9998304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01302725786246586,"score_gpt":0.3078928356666946,"score_spread":0.2948655778042288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}