{"id":"W2098232602","doi":"10.1128/iai.05109-11","title":"Helicobacter pylori Activates Calpain via Toll-Like Receptor 2 To Disrupt Adherens Junctions in Human Gastric Epithelial Cells","year":2011,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; St. Paul's Hospital; University of British Columbia; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Adherens junction; Biology; Helicobacter pylori; Toll-like receptor; Microbiology; Calpain; Helicobacter; Cell biology; Receptor; Immunology; Innate immune system; Genetics; Cell; Cadherin; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002161476,0.0001487687,0.0001170154,0.0001503201,0.0002212746,0.00002366259,0.00004930785,0.0001633011,0.0003295082],"category_scores_gemma":[0.00003594843,0.0001408168,0.00006809833,0.0002025377,0.00005590949,0.00001453493,0.00007206135,0.000170254,0.00004052448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003761515,"about_ca_system_score_gemma":0.00002051738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001358469,"about_ca_topic_score_gemma":0.0005738758,"domain_scores_codex":[0.9991347,0.0001782876,0.0002052373,0.0002335304,0.00006661563,0.0001816781],"domain_scores_gemma":[0.9995297,0.00000832781,0.00005978075,0.0002268895,0.0000653127,0.000110045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001398118,0.0001941232,0.01064602,0.000009276635,0.00002321516,3.62337e-7,0.0001849229,0.00001132298,0.982284,0.00001709468,0.0008412271,0.005648611],"study_design_scores_gemma":[0.0008666777,0.0007348891,0.2413583,0.00001863781,0.00001725091,0.0000192683,0.0001169536,0.00003549126,0.6820363,0.00008164607,0.07442013,0.0002943997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922348,0.00001853605,0.005947896,0.00004153094,0.0007209817,0.000302914,0.00001176487,0.00003284927,0.0006886749],"genre_scores_gemma":[0.9978758,0.00004652173,0.0001232679,0.000198838,0.0001662125,0.00005884616,0.00009570078,0.00001638551,0.001418483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3002476,"threshold_uncertainty_score":0.5742343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152193739167772,"score_gpt":0.2399872311888881,"score_spread":0.2247678572721109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}