{"id":"W2098232602","doi":"10.1128/iai.05109-11","title":"Helicobacter pylori Activates Calpain via Toll-Like Receptor 2 To Disrupt Adherens Junctions in Human Gastric Epithelial Cells","year":2011,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; St. Paul's Hospital; University of British Columbia; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Adherens junction; Biology; Helicobacter pylori; Toll-like receptor; Microbiology; Calpain; Helicobacter; Cell biology; Receptor; Immunology; Innate immune system; Genetics; Cell; Cadherin; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001546965,0.0002303002,0.0001649773,0.0001293603,0.0001060805,0.0002112223,0.0001348174,0.0002555049,0.0007359806],"category_scores_gemma":[0.00008136858,0.0001018543,0.0001884782,0.0001157881,0.00009178053,0.0001391695,0.0001546597,0.0003361763,0.0002537745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002314572,"about_ca_system_score_gemma":0.0001089452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005728328,"about_ca_topic_score_gemma":0.0006589383,"domain_scores_codex":[0.9998798,0.00002698327,0.00001085493,0.00001923177,0.00003663131,0.00002654855],"domain_scores_gemma":[0.9999766,0.000004073816,0.000005734356,0.000004517487,0.000004454572,0.000004614338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007006472,0.00004039604,0.0001975003,0.00003280505,0.000004822695,0.00009135871,0.00001402134,0.00002645253,0.9985348,0.00007848643,0.00005587288,0.000853406],"study_design_scores_gemma":[0.00007735514,0.0006706712,0.02276767,0.000009739855,0.00002395905,0.000991151,0.00006735849,0.002531517,0.9672992,0.0001188478,0.005436223,0.000006297591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987761,0.005972133,0.003324017,0.0002538501,0.00006840858,0.00005354601,0.0003409485,0.00006212234,0.00216388],"genre_scores_gemma":[0.9931345,0.002029803,0.001477289,0.0001166325,0.0000188144,0.00005093491,0.0005007337,0.000004874835,0.002666384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007359806,"threshold_uncertainty_score":0.002462089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152193739167772,"score_gpt":0.2399872311888881,"score_spread":0.2247678572721109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}