{"id":"W2098247131","doi":"10.1158/1535-7163.mct-06-0452","title":"The farnesyltransferase inhibitor R115777 (tipifarnib) in combination with tamoxifen acts synergistically to inhibit MCF-7 breast cancer cell proliferation and cell cycle progression <i>in vitro</i> and <i>in vivo</i>","year":2007,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Tamoxifen; Cancer research; Estrogen receptor; Pharmacology; Cell growth; Farnesyltransferase inhibitor; Farnesyltransferase; Cell cycle; Cell cycle checkpoint; Cancer; Biology; Breast cancer; Medicine; Internal medicine; Prenylation; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001881251,0.0005944244,0.0008036202,0.0006235716,0.0001666852,0.0003437714,0.0003106502,0.0004091045,0.001749559],"category_scores_gemma":[0.0001145973,0.0001882481,0.0005153396,0.0004441373,0.0001759837,0.0001820511,0.0002484944,0.0006448283,0.0005784092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003873686,"about_ca_system_score_gemma":0.0003548088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001050284,"about_ca_topic_score_gemma":0.003926028,"domain_scores_codex":[0.9998108,0.00003327508,0.00001594426,0.00002343276,0.0000533425,0.00006316633],"domain_scores_gemma":[0.99992,0.00001862097,0.00001865441,0.000006791534,0.000007728657,0.00002819403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009639439,0.0004339256,0.0005601786,0.000193945,0.00008430974,0.0001210301,0.00002372993,0.0004325752,0.9756961,0.0001209562,0.000528103,0.0208411],"study_design_scores_gemma":[0.0002201113,0.007996179,0.005182303,0.00001476697,0.0001404375,0.0007033601,0.00003299717,0.001094717,0.9778008,0.00003985958,0.006759851,0.00001463054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980169,0.009930818,0.00181784,0.0003357908,0.0001399081,0.0001743215,0.0007880221,0.0002717651,0.006372471],"genre_scores_gemma":[0.9851083,0.006111023,0.003730083,0.0001520292,0.00006790886,0.0001245077,0.001768932,0.00003821692,0.002899109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001749559,"threshold_uncertainty_score":0.005852818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003604603128011879,"score_gpt":0.2373296733041885,"score_spread":0.2337250701761766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}