{"id":"W2098247131","doi":"10.1158/1535-7163.mct-06-0452","title":"The farnesyltransferase inhibitor R115777 (tipifarnib) in combination with tamoxifen acts synergistically to inhibit MCF-7 breast cancer cell proliferation and cell cycle progression <i>in vitro</i> and <i>in vivo</i>","year":2007,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Tamoxifen; Cancer research; Estrogen receptor; Pharmacology; Cell growth; Farnesyltransferase inhibitor; Farnesyltransferase; Cell cycle; Cell cycle checkpoint; Cancer; Biology; Breast cancer; Medicine; Internal medicine; Prenylation; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003620137,0.0002614468,0.0001910319,0.00007696645,0.00009575639,0.00006525389,0.0001072051,0.0002413575,0.000001511732],"category_scores_gemma":[0.000005296778,0.0001967959,0.00002961339,0.0002646453,0.0001042944,0.00001522234,0.00005058736,0.0002562893,4.093922e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009632555,"about_ca_system_score_gemma":0.0001160396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001663333,"about_ca_topic_score_gemma":0.001406394,"domain_scores_codex":[0.9984664,0.0001192743,0.0002991439,0.0004504893,0.0002243158,0.0004403799],"domain_scores_gemma":[0.9995002,0.00003004212,0.00007003637,0.0001940559,0.00007623687,0.0001293934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00195773,0.0002306989,0.004848855,0.0000509658,0.00001908765,0.0000405484,0.000264086,0.0004531298,0.979845,0.00002339518,0.000007223068,0.01225932],"study_design_scores_gemma":[0.00272816,0.0003461774,0.002758622,0.0001227372,0.00002989526,0.00001481973,0.0000862448,0.0005909821,0.991927,0.00002608717,0.001075157,0.000294168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902855,0.006945788,0.000794147,0.0007384812,0.00007001324,0.0009070679,0.00002093405,0.00001080755,0.0002273134],"genre_scores_gemma":[0.9961475,0.002475773,0.0002064158,0.0008611756,0.00004658469,0.0001576476,0.000018205,0.00004698555,0.00003969583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01208199,"threshold_uncertainty_score":0.8025105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003604603128011879,"score_gpt":0.2373296733041885,"score_spread":0.2337250701761766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}