{"id":"W2098251455","doi":"10.1200/jco.2008.16.8310","title":"Performance of<i>BRCA1/2</i>Mutation Prediction Models in Asian Americans","year":2008,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health; Breast Cancer Research Foundation","keywords":"Mutation; Medicine; Genetics; Breast cancer; Cancer; Oncology; White (mutation); Internal medicine; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00452673,0.0009384052,0.0006603147,0.0007666185,0.0002417393,0.0009357447,0.0005526617,0.0005214163,0.00075228],"category_scores_gemma":[0.007618473,0.0002340773,0.0007865027,0.0003391128,0.0003327213,0.0004874509,0.0007653233,0.0005382723,0.0003118279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007029715,"about_ca_system_score_gemma":0.0006065137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009562153,"about_ca_topic_score_gemma":0.005886825,"domain_scores_codex":[0.9988386,0.0006463939,0.00006926383,0.000235041,0.0001290772,0.00008160659],"domain_scores_gemma":[0.9951486,0.003266201,0.0004921921,0.0002908795,0.0004815953,0.000320475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003818962,0.0004836544,0.895382,0.00008944763,0.0006464735,0.0001354858,0.0003136252,0.04604993,0.001058586,0.0002403875,0.001862085,0.04991949],"study_design_scores_gemma":[0.0002117546,0.001854581,0.2576867,0.00009670111,0.0005166882,0.0005717303,0.0005408394,0.7335428,0.00295419,0.0009050849,0.001060261,0.00005856036],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968917,0.0003712523,0.001542055,0.0001488262,0.00001173722,0.00001227744,0.0002229698,0.000113782,0.0006854871],"genre_scores_gemma":[0.9972028,0.0001208189,0.00180043,0.00006489571,0.000009417696,0.00001392042,0.0005656675,0.00001495753,0.0002072166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009562153,"threshold_uncertainty_score":0.02393997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08448750865067332,"score_gpt":0.4060021244815839,"score_spread":0.3215146158309106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}