{"id":"W2098257709","doi":"10.1016/j.clinthera.2011.07.014","title":"The Need for Additional Metrics to Assess Therapeutic Equivalence of Some Multiphasic Modified-Release Products","year":2011,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hamilton Health Sciences; University of Toronto; McMaster University","funders":"","keywords":"Medicine; Bioequivalence; Food and drug administration; Equivalence (formal languages); Statement (logic); Metric (unit); Position statement; Advisory committee; Drug; Pharmacology; Actuarial science; Medical physics; Family medicine; Pharmacokinetics; Law; Operations management; Public administration; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.009537883,0.0003875794,0.001115544,0.0001166789,0.0002550531,0.00005117258,0.001299429,0.0004004613,0.0002671177],"category_scores_gemma":[0.1497839,0.0002624063,0.0005599764,0.0007363116,0.0009077368,0.0001101308,0.0002235824,0.0006174122,0.00003643612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005402622,"about_ca_system_score_gemma":0.0002844277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002147533,"about_ca_topic_score_gemma":0.000001100727,"domain_scores_codex":[0.9934817,0.001540762,0.002776716,0.0007401764,0.0007644231,0.0006962546],"domain_scores_gemma":[0.7907345,0.2056362,0.0009080701,0.00133437,0.001073991,0.000312848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0018591,0.00242682,0.0003014748,0.0002328648,0.0008776514,0.000004138868,0.0001798914,0.00000717833,0.0004350489,0.7326519,0.005203924,0.25582],"study_design_scores_gemma":[0.001811244,0.001315269,0.001077732,0.0000892102,0.0004839934,0.000001742457,0.00008274217,0.00199379,0.003168933,0.9804162,0.009175896,0.0003832547],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.01548285,0.0007996685,0.9633731,0.002828602,0.006596119,0.005923423,0.003357428,0.0003142543,0.00132454],"genre_scores_gemma":[0.126183,0.0003706635,0.8681524,0.003080494,0.001084138,0.0004692656,0.00001311284,0.0001255595,0.000521408],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.2554367,"threshold_uncertainty_score":0.9999828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8843704126214491,"score_gpt":0.6060957014774468,"score_spread":0.2782747111440023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}