{"id":"W2098260035","doi":"10.1107/s0907444911014302","title":"Structure-based design of a disulfide-linked oligomeric form of the simian virus 40 (SV40) large T antigen DNA-binding domain","year":2011,"lang":"en","type":"article","venue":"Acta Crystallographica Section D Biological Crystallography","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Brookhaven National Laboratory; National Institutes of Health","keywords":"DNA; DNA replication; Origin of replication; Chemistry; Intermolecular force; Biology; Crystallography; Stereochemistry; Molecule; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002352013,0.0003465081,0.0002807225,0.0002292631,0.0002518938,0.0004993137,0.000682511,0.0004015162,0.000979737],"category_scores_gemma":[0.0002336746,0.0002823322,0.0003072043,0.0003039258,0.0002206427,0.0002292705,0.0002426866,0.0008159027,0.0003748648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006933424,"about_ca_system_score_gemma":0.0005495297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001142115,"about_ca_topic_score_gemma":0.0009575115,"domain_scores_codex":[0.9998801,0.00002542381,0.00001251893,0.00001907034,0.00004372878,0.00001912609],"domain_scores_gemma":[0.9999175,0.000009021003,0.00002269042,0.000008504997,0.00001822534,0.0000240401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003779172,0.0003605932,0.000395163,0.0001329412,0.00003232258,0.0002855927,0.00007552803,0.01189739,0.977001,0.002441007,0.0002651234,0.006735236],"study_design_scores_gemma":[0.0003126285,0.00116272,0.001528493,0.00002387043,0.00006973803,0.0003246943,0.0001043449,0.04223056,0.9393538,0.0005540022,0.01430656,0.00002849879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980587,0.0008082246,0.01426808,0.0002144762,0.00004789807,0.000255023,0.0004828544,0.0001138193,0.003222513],"genre_scores_gemma":[0.9598901,0.001221244,0.03482944,0.00006705925,0.00001009431,0.0001070992,0.001372683,0.00004413693,0.002458216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001142115,"threshold_uncertainty_score":0.005030513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02956862534850241,"score_gpt":0.2394886228747737,"score_spread":0.2099199975262713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}