{"id":"W2098270787","doi":"10.1056/nejmoa1201622","title":"Combination Anastrozole and Fulvestrant in Metastatic Breast Cancer","year":2012,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":374,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre","funders":"National Cancer Institute; U.S. Public Health Service","keywords":"Anastrozole; Fulvestrant; Medicine; Metastatic breast cancer; Aromatase inhibitor; Aromatase; Internal medicine; Breast cancer; Oncology; Estrogen receptor; Estrogen; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006423971,0.0003474707,0.001024389,0.000485225,0.0001812965,0.0001967823,0.0002898376,0.0002746238,0.001448863],"category_scores_gemma":[0.0007643809,0.0001412759,0.0003480933,0.0003669408,0.0002076707,0.0001968831,0.000219692,0.0004841586,0.0002224713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003938075,"about_ca_system_score_gemma":0.0003868378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003706367,"about_ca_topic_score_gemma":0.00174812,"domain_scores_codex":[0.9996957,0.0001438775,0.00002348151,0.00003279699,0.00006730174,0.00003685785],"domain_scores_gemma":[0.9997596,0.00008432728,0.0000484133,0.00001385502,0.00001559774,0.00007825454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2548303,0.006564023,0.03551321,0.002145859,0.002276429,0.00101703,0.0002231727,0.005455466,0.05404931,0.0004989122,0.003230799,0.6341955],"study_design_scores_gemma":[0.1163957,0.6645162,0.151283,0.0005804041,0.004467223,0.005393747,0.0001671817,0.004627306,0.01734266,0.001510913,0.03363705,0.00007856444],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9677371,0.02916446,0.0004483531,0.0003973566,0.00009724848,0.0002337078,0.0001131664,0.00002771307,0.001780992],"genre_scores_gemma":[0.9915512,0.006778034,0.000714667,0.0001458982,0.0001392934,0.0001549624,0.0001577158,0.000002879531,0.0003555927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001448863,"threshold_uncertainty_score":0.004846931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008476323395381435,"score_gpt":0.2691481987057084,"score_spread":0.2606718753103269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}