{"id":"W2098332826","doi":"10.1124/jpet.104.065185","title":"Obligatory Role for Endogenous Endothelin in Mediating the Hypertrophic Effects of Phenylephrine and Angiotensin II in Neonatal Rat Ventricular Myocytes: Evidence for Two Distinct Mechanisms for Endothelin Regulation","year":2004,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Phenylephrine; Internal medicine; Endothelin receptor; Angiotensin II; Endogeny; Renin–angiotensin system; Endocrinology; Endothelin 1; Myocyte; Chemistry; Medicine; Receptor; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009750656,0.0003654625,0.0006277143,0.0003075709,0.000409295,0.0006998962,0.0007048207,0.0005876589,0.00127689],"category_scores_gemma":[0.00103319,0.0004108313,0.0004462203,0.0001522261,0.0009995021,0.001359899,0.0009329786,0.001059766,0.0001839371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005120023,"about_ca_system_score_gemma":0.0005066746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004213194,"about_ca_topic_score_gemma":0.001000727,"domain_scores_codex":[0.999447,0.0001031074,0.00008501891,0.00009953766,0.0001478676,0.00011743],"domain_scores_gemma":[0.9982377,0.0006636515,0.0002672451,0.0003440871,0.0001756415,0.0003116348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004535929,0.00003993374,0.0005354882,0.00007660031,0.00001130255,0.0002980994,0.00009798928,0.00002230934,0.9961825,0.001070845,0.00001543143,0.001195836],"study_design_scores_gemma":[0.000234856,0.001336642,0.09894716,0.00009483647,0.0001587279,0.002071225,0.0004266258,0.001497653,0.8911477,0.001390748,0.002661536,0.0000323112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802558,0.009053704,0.007154001,0.0003190868,0.0001068401,0.00004721244,0.0001816532,0.00004289786,0.002838847],"genre_scores_gemma":[0.9899478,0.002242267,0.005080929,0.0001066577,0.00006130186,0.00009590071,0.0001356804,0.00002000519,0.002309556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00127689,"threshold_uncertainty_score":0.005156755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03271431357295237,"score_gpt":0.3286972219154354,"score_spread":0.295982908342483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}