{"id":"W2098356010","doi":"10.1038/nm.2661","title":"Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia","year":2012,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":654,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Institute of Cancer Research; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Myeloid leukemia; Cancer research; Acute promyelocytic leukemia; Biology; Leukemia; Tretinoin; Demethylase; Myeloid; Retinoic acid; Immunology; Epigenetics; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003058894,0.000243065,0.0002868604,0.000274854,0.0001911194,0.000337636,0.0002991077,0.0001746391,0.002025375],"category_scores_gemma":[0.0001609503,0.0001895757,0.0002731648,0.0001721797,0.0002953933,0.0001750622,0.0001680878,0.0006535343,0.0004793825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003803999,"about_ca_system_score_gemma":0.0003568523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006724093,"about_ca_topic_score_gemma":0.001661201,"domain_scores_codex":[0.9998534,0.00002561711,0.00002037372,0.00001867486,0.00003769664,0.00004428388],"domain_scores_gemma":[0.9999181,0.00001671745,0.00002081419,0.00001722083,0.000006746926,0.00002024096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008305077,0.000122255,0.0005894289,0.00005253818,0.00002436216,0.00006324689,0.00001819514,0.0003890982,0.9891456,0.0006068144,0.0004141153,0.007743793],"study_design_scores_gemma":[0.00009023114,0.0004276909,0.002118962,0.00000286634,0.00002236509,0.0001651723,0.00001739161,0.0008899726,0.9927776,0.0000838444,0.003400223,0.000003649165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923774,0.002147736,0.002344186,0.0002867045,0.00008061463,0.00002712074,0.0003460079,0.0002298631,0.002160421],"genre_scores_gemma":[0.9957922,0.000817774,0.0008529572,0.00004577252,0.000009688743,0.00001862435,0.0003329182,0.00001854856,0.002111475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002025375,"threshold_uncertainty_score":0.006775498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008411413880603855,"score_gpt":0.2726679563473253,"score_spread":0.2642565424667214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}