{"id":"W2098356010","doi":"10.1038/nm.2661","title":"Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia","year":2012,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":654,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Institute of Cancer Research; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Myeloid leukemia; Cancer research; Acute promyelocytic leukemia; Biology; Leukemia; Tretinoin; Demethylase; Myeloid; Retinoic acid; Immunology; Epigenetics; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007442022,0.0001727587,0.0001906754,0.00008209265,0.00007795816,0.000004586891,0.0002396663,0.0004200964,0.00003098967],"category_scores_gemma":[0.0005131736,0.00009370523,0.00008561994,0.0002990449,0.0003513035,0.00001025147,0.00008821434,0.0008028474,0.000003121369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009860021,"about_ca_system_score_gemma":0.00009132643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006848397,"about_ca_topic_score_gemma":0.0001236891,"domain_scores_codex":[0.9984049,0.0002734526,0.0002924247,0.0002284795,0.0004742339,0.0003265378],"domain_scores_gemma":[0.999157,0.00006049438,0.0001421826,0.000450311,0.0001125269,0.00007750738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000106267,0.00006712229,0.00114292,0.00002593928,0.00004268107,0.00000163516,0.0005221841,0.000003398533,0.9946215,0.00006767178,0.002264685,0.001133979],"study_design_scores_gemma":[0.0008315017,0.0001445755,0.01115905,0.00008468042,0.00003286138,0.00001361423,0.0001428262,0.00001146218,0.9784253,0.00004638244,0.009010168,0.00009759692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911329,0.004166147,0.00009037264,0.003194914,0.0004128799,0.0003523973,0.00002023057,0.000008000859,0.000622188],"genre_scores_gemma":[0.9981223,0.0002376233,0.00003161827,0.0004768911,0.0006356386,0.00003362019,0.0002087007,0.00002260851,0.0002310122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01619623,"threshold_uncertainty_score":0.3821189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008411413880603855,"score_gpt":0.2726679563473253,"score_spread":0.2642565424667214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}