{"id":"W2098395472","doi":"10.1158/1541-7786.mcr-12-0510","title":"Human Papilloma Virus (HPV) E7-Mediated Attenuation of Retinoblastoma (Rb) Induces hPygopus2 Expression via Elf-1 in Cervical Cancer","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research","keywords":"Cancer research; Cervical cancer; Retinoblastoma; Biology; RNA interference; Chromatin immunoprecipitation; Cancer; HeLa; Transfection; Retinoblastoma protein; Derepression; Molecular biology; Cell culture; Gene expression; Promoter; Psychological repression; Cell cycle; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001098928,0.0002604875,0.0002249968,0.0002157411,0.0001562254,0.0002462739,0.0001343234,0.0001832568,0.001129236],"category_scores_gemma":[0.00007562436,0.0001483949,0.0003001347,0.0001305472,0.0002034933,0.0001332422,0.0002148099,0.0003921849,0.0003458562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003168574,"about_ca_system_score_gemma":0.0002232667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026113,"about_ca_topic_score_gemma":0.00142661,"domain_scores_codex":[0.9999028,0.00001128583,0.000008007674,0.00002430568,0.00002436743,0.00002924924],"domain_scores_gemma":[0.9999523,0.000008167907,0.00001148813,0.000007548074,0.000006012021,0.0000145679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000444866,0.00001255226,0.0001370289,0.00001809212,0.000001979158,0.00001701999,0.00000913421,0.00001646073,0.9993644,0.00003265221,0.00001620884,0.0003299455],"study_design_scores_gemma":[0.000007074751,0.00009643142,0.004252865,0.000003117054,0.000007086494,0.00007201465,0.00001658415,0.000487358,0.9937843,0.00001639698,0.001254626,0.000002098729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949784,0.001180585,0.002016684,0.00006083252,0.0000235745,0.00002926394,0.0004197961,0.00009333486,0.00119745],"genre_scores_gemma":[0.9938179,0.0007001399,0.001649346,0.0000438389,0.00000517015,0.00003689709,0.0007552102,0.00002498535,0.002966491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001129236,"threshold_uncertainty_score":0.003777683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03169226104888779,"score_gpt":0.3462654474775781,"score_spread":0.3145731864286904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}