{"id":"W2098412954","doi":"10.1093/hmg/ddp033","title":"Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients","year":2009,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"Coalition for Research in Women's Health; University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute for Health and Care Research; University College London; Cancer Research UK","keywords":"Breast cancer; DNA methylation; Biology; CDKN2A; Epigenetics; Cancer; MLH1; Methylation; GSTP1; Carcinogenesis; Genetic predisposition; Cancer research; Oncology; Genetics; Internal medicine; Gene; Medicine; Genotype; Colorectal cancer; Gene expression; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001157423,0.0001924096,0.0002352015,0.0001046277,0.00003309234,0.00001046534,0.0001832494,0.000186166,0.00002281432],"category_scores_gemma":[0.00001319253,0.00020662,0.0001174067,0.0001510672,0.00006803429,0.000003885486,0.00005312034,0.00007192756,4.481058e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001636467,"about_ca_system_score_gemma":0.00005253282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006382246,"about_ca_topic_score_gemma":0.00004775323,"domain_scores_codex":[0.9986202,0.00008922406,0.0004929356,0.0003277905,0.0002369373,0.0002329607],"domain_scores_gemma":[0.9991297,0.00000341445,0.000222043,0.000351904,0.0002291972,0.00006379291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003422992,0.0002945898,0.1033652,0.00001649617,0.0000323879,0.000001899431,0.00007539874,0.00173594,0.8920271,0.0000310162,0.000003491736,0.002382212],"study_design_scores_gemma":[0.0006752773,0.0003673833,0.4561016,0.00001302113,0.0000277488,7.359451e-7,0.000003137905,0.00006228741,0.5423569,0.000247549,0.00002219563,0.0001221792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972466,0.001814584,0.0003184444,0.00001842047,0.00006086749,0.0002336877,0.00005790148,0.000004529583,0.0002449544],"genre_scores_gemma":[0.9984872,0.000366035,0.0007624311,0.0000488623,0.00006614918,0.000007791708,0.0002032842,0.00002668238,0.00003159836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3527364,"threshold_uncertainty_score":0.8425719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006883930521021423,"score_gpt":0.257743632041446,"score_spread":0.2508597015204246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}