{"id":"W2098415496","doi":"10.1101/gad.221739.113","title":"Glycogen synthase kinase 3 promotes p53 mRNA translation via phosphorylation of RNPC1","year":2013,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; University of Toronto","keywords":"Biology; GSK-3; Translation (biology); Phosphorylation; Eukaryotic initiation factor; EIF4G; Messenger RNA; GSK3B; Molecular biology; EIF4E; Translational regulation; Kinase; Eukaryotic translation; Repressor; Cell biology; Biochemistry; Gene expression; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000155462,0.0001872547,0.0002545584,0.0001342083,0.00006326151,0.00001181657,0.00007208902,0.0001254265,0.0005400943],"category_scores_gemma":[0.00002497168,0.0001779717,0.0000773647,0.0002349749,0.00003802212,0.00008378622,0.00002450336,0.00009515334,0.0002073138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001626085,"about_ca_system_score_gemma":0.000330881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001134472,"about_ca_topic_score_gemma":0.00002355784,"domain_scores_codex":[0.9985947,0.00002717351,0.0004631347,0.0002876413,0.0003796378,0.0002476817],"domain_scores_gemma":[0.9992395,0.0000210549,0.0001387939,0.0002586959,0.0002053079,0.0001366697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006873345,0.0001151966,0.0008438347,0.00009899022,0.00009423469,0.00001176114,0.0009619734,0.00003901748,0.5370189,0.000008056673,0.0001328701,0.4606065],"study_design_scores_gemma":[0.001212802,0.000125279,0.01754031,0.0001614767,0.00008549784,0.00003129027,0.00005003086,0.0008611355,0.9690225,0.00008995309,0.01060698,0.0002127268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809242,0.003708451,0.01266703,0.0003596579,0.0002205472,0.001293062,0.000004639549,0.00008200441,0.0007404098],"genre_scores_gemma":[0.9697329,0.0001164978,0.02954874,0.00008378238,0.00004986526,0.0001569944,0.000132751,0.00003629729,0.0001421335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4603937,"threshold_uncertainty_score":0.7257474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633816397891841,"score_gpt":0.2341309438765218,"score_spread":0.2177927798976033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}