{"id":"W2098418963","doi":"10.1093/eurjhf/hft052","title":"Dual Angiotensin Receptor and Neprilysin Inhibition as an Alternative to Angiotensin-Converting Enzyme Inhibition in Patients with Chronic Systolic Heart Failure: Rationale for and Design of the Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure Trial (PARADIGM-HF)","year":2013,"lang":"en","type":"article","venue":"European Journal of Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":452,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Novartis Pharma","keywords":"Enalapril; Medicine; Heart failure; Neprilysin; Sacubitril; Internal medicine; Cardiology; Valsartan; Renin–angiotensin system; Natriuretic peptide; ACE inhibitor; Natriuresis; Ejection fraction; Pharmacology; Angiotensin-converting enzyme; Endocrinology; Blood pressure; Chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003569695,0.00170458,0.003933673,0.0003884943,0.0004975899,0.001179776,0.001044317,0.002037927,0.002958759],"category_scores_gemma":[0.002030964,0.0007927133,0.001745237,0.0004129967,0.001256607,0.001174337,0.0006525454,0.003133604,0.0006510715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005907732,"about_ca_system_score_gemma":0.001238813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004532622,"about_ca_topic_score_gemma":0.001381751,"domain_scores_codex":[0.9981009,0.001028486,0.0001575224,0.0003398592,0.0001397789,0.0002334411],"domain_scores_gemma":[0.9988318,0.0002425873,0.0002162509,0.00009995692,0.00008390447,0.0005255139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9841834,0.004407912,0.00139446,0.0002151302,0.0004626449,0.00002221607,0.00001981055,0.0001893834,0.001736512,0.0001174839,0.0001192844,0.007131892],"study_design_scores_gemma":[0.8387545,0.1531762,0.005211859,0.00004497924,0.000868018,0.00004051003,0.00001988105,0.0004450851,0.0005312354,0.0002714696,0.0006104108,0.00002595291],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.978058,0.008371982,0.001149031,0.001179872,0.000783371,0.007089259,0.0008910411,0.00005808561,0.002419274],"genre_scores_gemma":[0.9833487,0.00237647,0.002976177,0.001285796,0.001042456,0.007047659,0.0007154869,0.00001238723,0.001194947],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.003933673,"threshold_uncertainty_score":0.01887858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02867095127254463,"score_gpt":0.2881548921477827,"score_spread":0.2594839408752381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}