{"id":"W2098418963","doi":"10.1093/eurjhf/hft052","title":"Dual Angiotensin Receptor and Neprilysin Inhibition as an Alternative to Angiotensin-Converting Enzyme Inhibition in Patients with Chronic Systolic Heart Failure: Rationale for and Design of the Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure Trial (PARADIGM-HF)","year":2013,"lang":"en","type":"article","venue":"European Journal of Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":452,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Novartis Pharma","keywords":"Enalapril; Medicine; Heart failure; Neprilysin; Sacubitril; Internal medicine; Cardiology; Valsartan; Renin–angiotensin system; Natriuretic peptide; ACE inhibitor; Natriuresis; Ejection fraction; Pharmacology; Angiotensin-converting enzyme; Endocrinology; Blood pressure; Chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007873536,0.0003113714,0.0007928228,0.0002613432,0.00008792934,0.00005555727,0.000041351,0.00005892634,0.00001059754],"category_scores_gemma":[0.0001445355,0.0001998004,0.00008969352,0.0003823679,0.0001331473,0.0003954241,0.00005624177,0.0002528369,0.000002645148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002961502,"about_ca_system_score_gemma":0.0001650229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002683283,"about_ca_topic_score_gemma":0.0005995443,"domain_scores_codex":[0.9975342,0.0005714934,0.0007237372,0.0003860785,0.0004826582,0.0003018968],"domain_scores_gemma":[0.9986517,0.0001055301,0.0003803157,0.0002257337,0.0003707518,0.0002659443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03832094,0.001840801,0.8997386,0.0002076264,0.0004760222,0.00005940672,0.003911387,0.003159037,0.02531752,0.00007884784,0.02636309,0.0005266846],"study_design_scores_gemma":[0.03045643,0.02361251,0.9323764,0.001523349,0.0001603266,0.0001543647,0.0003640452,0.000422655,0.01003133,0.00003911101,0.0006010996,0.0002584027],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780522,0.00004344142,0.000396476,0.0170577,0.00003895129,0.004374322,0.00002640513,0.000009025196,0.000001485608],"genre_scores_gemma":[0.9814897,0.000001517188,0.01804506,0.0002345447,0.0001543518,0.00002442987,0.00001671193,0.00002941579,0.000004320471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03263774,"threshold_uncertainty_score":0.8147625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02867095127254463,"score_gpt":0.2881548921477827,"score_spread":0.2594839408752381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}