{"id":"W2098492915","doi":"10.1136/bmjopen-2014-006141","title":"Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium","year":2014,"lang":"en","type":"review","venue":"BMJ Open","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Baycrest Hospital; University of Toronto","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Agency for Healthcare Research and Quality; National Institutes of Health; Koç Üniversitesi; University of Bristol; H. Lundbeck A/S; Egmont Fonden; National Center for Advancing Translational Sciences; Economic and Social Research Council; Emil Aaltosen Säätiö; Augustinus Fonden; United Kingdom Clinical Research Collaboration; Oulun Yliopisto; National Health and Medical Research Council; Medical Research Council; Signe ja Ane Gyllenbergin Säätiö; Novo Nordisk; Juho Vainion Säätiö; National Institute of Diabetes and Digestive and Kidney Diseases; Norwegian Institute of Public Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Samfundet Folkhälsan; Academy of Finland; ZonMw; Wellcome Trust; Cancer Research UK; National Institute of Mental Health; Danmarks Grundforskningsfond; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Helsingin Yliopisto; European Commission; Folkhälsanin Tutkimussäätiö; Biocenter, University of Oulu; National Institute for Health and Care Research; National Research Foundation; British Heart Foundation; National Institute on Aging; Erasmus Medisch Centrum; Erasmus Universiteit Rotterdam; Vrije Universiteit Amsterdam; University of Oxford; Health and Safety Executive; National Institute on Drug Abuse; John D. and Catherine T. MacArthur Foundation; Eli Lilly and Company; Finska Läkaresällskapet; Norges Teknisk-Naturvitenskapelige Universitet; March of Dimes Foundation; Pfizer; Heart and Stroke Foundation of Canada; National Science Foundation","keywords":"Medicine; Depression (economics); Anxiety; Meta-analysis; Psychiatry; Association (psychology); Mendelian randomization; Family medicine; Internal medicine; Genotype; Genetics; Genetic variants; Psychotherapist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06426618,0.00391726,0.01239085,0.004130875,0.0008970308,0.003593113,0.003625158,0.004221515,0.00527527],"category_scores_gemma":[0.1273717,0.002182492,0.03497953,0.005858816,0.0009956743,0.001636351,0.001662886,0.002666899,0.0004092348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001294475,"about_ca_system_score_gemma":0.002886474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009270054,"about_ca_topic_score_gemma":0.006039035,"domain_scores_codex":[0.9129261,0.07202898,0.005619763,0.006012938,0.002560286,0.0008519373],"domain_scores_gemma":[0.9342411,0.05115455,0.005834406,0.006208096,0.002091894,0.000470049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.01084698,0.00004294638,0.01534364,0.01991271,0.9411231,0.0002932726,0.00008696024,0.001787866,0.0003920598,0.000740978,0.001529553,0.007899806],"study_design_scores_gemma":[0.01308845,0.0005006196,0.007684205,0.002173666,0.9661723,0.0002726947,0.00003392178,0.004862578,0.0002400672,0.002998283,0.001906113,0.00006714208],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1444294,0.679029,0.1406664,0.007336765,0.005410691,0.009164177,0.009136327,0.002286722,0.002540494],"genre_scores_gemma":[0.8677692,0.0503695,0.05524786,0.003454999,0.001375132,0.01537482,0.004284668,0.0004864831,0.001637312],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.06426618,"threshold_uncertainty_score":0.3398761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1436319404420811,"score_gpt":0.4148065035165714,"score_spread":0.2711745630744903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}