{"id":"W2098493843","doi":"10.1074/jbc.m200197200","title":"Human ING1 Proteins Differentially Regulate Histone Acetylation","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Genome Prairie; University of Calgary","funders":"Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; National Cancer Institute; Edward Mallinckrodt, Jr. Foundation; Canadian Institutes of Health Research; American Association for Cancer Research","keywords":"PCAF; P300-CBP Transcription Factors; Acetylation; Histone; Proliferating cell nuclear antigen; Chromatin remodeling; Chromatin; Histone acetyltransferase; Biology; Molecular biology; Histone H2A; Histone H4; Histone H3; SAP30; Histone deacetylase 2; Nuclear protein; HDAC11; Cell biology; Histone deacetylase 5; Histone code; Histone deacetylase; Histone Acetyltransferases; DNA; Biochemistry; Transcription factor; Nucleosome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002072142,0.0001611533,0.0002240073,0.00001899666,0.00007239047,0.00002014925,0.0002760496,0.0003282014,0.0005629954],"category_scores_gemma":[0.0001495976,0.0001216992,0.0002072052,0.00005395907,0.00009090488,0.000005085004,0.00009868748,0.0002148754,0.000005633889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003773491,"about_ca_system_score_gemma":0.00001419246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.567615e-7,"about_ca_topic_score_gemma":3.780015e-7,"domain_scores_codex":[0.9989337,0.00004633174,0.0004265469,0.0002143921,0.0001768355,0.0002021975],"domain_scores_gemma":[0.9991153,0.000006018913,0.0003973603,0.0002284871,0.0001296352,0.0001231333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003737238,0.0001413114,0.0002821665,0.00001565474,0.00004093812,0.00001472558,0.00001109183,0.000009896352,0.997582,0.00001324205,0.0009160899,0.0009354891],"study_design_scores_gemma":[0.0005705223,0.0004571706,0.001225979,0.0000248145,0.00001675446,0.0001644146,0.000013966,0.0000306367,0.9917598,0.0002463116,0.005323201,0.0001664628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968429,0.0005643186,0.0004855698,0.0001458463,0.000080624,0.00007734376,0.000003665095,0.00001413078,0.00178563],"genre_scores_gemma":[0.9957439,0.00008380796,0.001190804,0.00006849364,0.0005503652,0.000004024313,0.0000179539,0.00001339174,0.002327224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005822255,"threshold_uncertainty_score":0.6164405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02302579035783155,"score_gpt":0.2564993992861068,"score_spread":0.2334736089282753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}