{"id":"W2098493843","doi":"10.1074/jbc.m200197200","title":"Human ING1 Proteins Differentially Regulate Histone Acetylation","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Genome Prairie; University of Calgary","funders":"Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; National Cancer Institute; Edward Mallinckrodt, Jr. Foundation; Canadian Institutes of Health Research; American Association for Cancer Research","keywords":"PCAF; P300-CBP Transcription Factors; Acetylation; Histone; Proliferating cell nuclear antigen; Chromatin remodeling; Chromatin; Histone acetyltransferase; Biology; Molecular biology; Histone H2A; Histone H4; Histone H3; SAP30; Histone deacetylase 2; Nuclear protein; HDAC11; Cell biology; Histone deacetylase 5; Histone code; Histone deacetylase; Histone Acetyltransferases; DNA; Biochemistry; Transcription factor; Nucleosome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001156554,0.0003866483,0.0001418834,0.0002000209,0.0001884559,0.0003302289,0.0001283864,0.0001847939,0.002091876],"category_scores_gemma":[0.0001185536,0.0001309436,0.0002229695,0.0002014505,0.0001518451,0.000126313,0.000231669,0.0002947084,0.0009492167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003747506,"about_ca_system_score_gemma":0.0001104815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005373875,"about_ca_topic_score_gemma":0.001110338,"domain_scores_codex":[0.9998702,0.00001346976,0.000005888764,0.0000311597,0.00002972381,0.00004969155],"domain_scores_gemma":[0.9999275,0.00001150702,0.00001785693,0.00001253874,0.000009706255,0.00002084575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001658157,0.0000177308,0.0008851795,0.00004158043,0.000009519967,0.00006632543,0.0000246354,0.00006131579,0.9954597,0.0001368762,0.0001237774,0.003007564],"study_design_scores_gemma":[0.000009421919,0.00009073557,0.01522583,0.000006345843,0.0000288786,0.0005262764,0.00004215421,0.0004260197,0.9763945,0.00008386509,0.007161215,0.00000473023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908318,0.003671572,0.00212438,0.0001207885,0.00002913804,0.00001652795,0.0005669676,0.0001576941,0.002481056],"genre_scores_gemma":[0.9880897,0.001694597,0.002000061,0.0001240089,0.000009207491,0.00002315951,0.002333705,0.00004070105,0.005684911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002091876,"threshold_uncertainty_score":0.006998062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02302579035783155,"score_gpt":0.2564993992861068,"score_spread":0.2334736089282753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}