{"id":"W2098507056","doi":"10.1002/chem.200800065","title":"A Novel Linker Methodology for the Synthesis of Tailored Conjugate Vaccines Composed of Complex Carbohydrate Antigens and Specific T<sub>H</sub>‐Cell Peptide Epitopes","year":2008,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Glycomics Centre","keywords":"Epitope; Glycopeptide; Biotinylation; Peptide; Antigen; Linker; Candida albicans; Biochemistry; Glycoprotein; Chemistry; Conjugate vaccine; Biology; Microbiology; Immunogenicity; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002716621,0.0006002763,0.0001990656,0.0003356281,0.0002230696,0.0002263513,0.0003494108,0.0004782968,0.001476473],"category_scores_gemma":[0.0001876392,0.0003098081,0.0002603892,0.0002354407,0.0002603946,0.0005041874,0.0004169261,0.0008702567,0.0008428411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002362191,"about_ca_system_score_gemma":0.000397576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001744803,"about_ca_topic_score_gemma":0.0003612634,"domain_scores_codex":[0.9998746,0.00002107592,0.000009791619,0.00003780418,0.00003656557,0.00002009429],"domain_scores_gemma":[0.9999098,0.00001866956,0.00003395697,0.00001382378,0.000009899916,0.00001390834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003190056,0.00003359066,0.00007052332,0.0001599736,0.00001094323,0.00009518001,0.00003394978,0.000202083,0.9874691,0.001048784,0.0001470079,0.01069701],"study_design_scores_gemma":[0.00003505098,0.0003349039,0.0005721447,0.00001299629,0.00002888849,0.0009789724,0.00001184937,0.0007928577,0.9773766,0.0003721511,0.01946867,0.00001486787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3714986,0.01032701,0.6048707,0.0006320569,0.0003789574,0.0007606392,0.0007275437,0.001154702,0.009649783],"genre_scores_gemma":[0.6175128,0.01047053,0.3544941,0.0006262673,0.0001129679,0.0007568315,0.001008144,0.0002303852,0.01478799],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001476473,"threshold_uncertainty_score":0.004939258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07352686392679764,"score_gpt":0.274318934912508,"score_spread":0.2007920709857103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}