{"id":"W2098511833","doi":"10.7554/elife.01846","title":"In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes","year":2014,"lang":"en","type":"article","venue":"eLife","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Japan Society for the Promotion of Science; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Juvenile Diabetes Research Foundation International","keywords":"Reprogramming; Islet; In vivo; Endocrine system; Enteroendocrine cell; Pancreas; Cell biology; Biology; Pancreatic islets; Endocrinology; Internal medicine; Cancer research; Insulin; Medicine; Genetics; Cell; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003139847,0.00041599,0.0002808861,0.0002725727,0.0002022943,0.0005593126,0.0003216459,0.0003574213,0.001861969],"category_scores_gemma":[0.0001671671,0.0001970292,0.0004679318,0.0001939707,0.0003043619,0.0002936507,0.0004006239,0.001068746,0.0006354697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002511501,"about_ca_system_score_gemma":0.0002374781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003314505,"about_ca_topic_score_gemma":0.0008350544,"domain_scores_codex":[0.9997596,0.00003205761,0.0000316812,0.00007426833,0.00006501403,0.00003723287],"domain_scores_gemma":[0.9998513,0.00003098162,0.00003113131,0.00003671364,0.00001214332,0.00003768165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005861852,0.00002393862,0.000186119,0.00002781437,0.000006044297,0.00004085303,0.00002548008,0.00008232336,0.9964893,0.0002729564,0.00004731475,0.002739271],"study_design_scores_gemma":[0.00001598863,0.0001139463,0.001430286,0.000006854897,0.00002395281,0.000217915,0.0000381322,0.0005112115,0.9905337,0.0001702611,0.006932675,0.000005066699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9018862,0.002779315,0.07648522,0.0004003322,0.0002566858,0.0002363082,0.002051435,0.0006391064,0.01526551],"genre_scores_gemma":[0.9500277,0.002279186,0.03521509,0.0002234728,0.00002889352,0.0001937125,0.001450256,0.0001960086,0.01038571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001861969,"threshold_uncertainty_score":0.006228864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0125368586326689,"score_gpt":0.2591645211387624,"score_spread":0.2466276625060935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}