{"id":"W2098511833","doi":"10.7554/elife.01846","title":"In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes","year":2014,"lang":"en","type":"article","venue":"eLife","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Japan Society for the Promotion of Science; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Juvenile Diabetes Research Foundation International","keywords":"Reprogramming; Islet; In vivo; Endocrine system; Enteroendocrine cell; Pancreas; Cell biology; Biology; Pancreatic islets; Endocrinology; Internal medicine; Cancer research; Insulin; Medicine; Genetics; Cell; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002716722,0.0001053621,0.0003625189,0.0001343313,0.00001742027,0.000005842492,0.0000562207,0.00003569035,0.0004695072],"category_scores_gemma":[0.0008726288,0.00008831271,0.00005576295,0.00024471,0.00002888769,0.00003712659,0.0000298169,0.00007760962,0.000155476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002447265,"about_ca_system_score_gemma":0.00002660493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001822421,"about_ca_topic_score_gemma":0.00002774002,"domain_scores_codex":[0.9990524,0.00002941612,0.0002716607,0.0002042793,0.0002199848,0.0002222494],"domain_scores_gemma":[0.9992163,0.0001485617,0.00005623292,0.0003559848,0.00009232568,0.0001306531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004016481,0.0003578138,0.3601642,0.0003718606,0.00007938821,0.00003397822,0.0005243909,0.00004114088,0.6026874,0.0009681827,0.02750003,0.006870036],"study_design_scores_gemma":[0.001886943,0.000732253,0.03262827,0.0002509659,0.00008615527,0.000009491462,0.0001261653,0.0004573751,0.8520908,0.0001351747,0.1114416,0.0001547486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989417,0.0001470278,0.0004094081,0.0006421485,0.0002121479,0.0002597737,0.000002461036,0.00004369757,0.008866332],"genre_scores_gemma":[0.991721,0.00001868409,0.00421821,0.00150414,0.0002412851,0.00002606448,0.000002661487,0.0000156348,0.002252256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3275359,"threshold_uncertainty_score":0.5140775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0125368586326689,"score_gpt":0.2591645211387624,"score_spread":0.2466276625060935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}