{"id":"W2098559309","doi":"10.1161/hypertensionaha.108.127670","title":"Tumor Necrosis Factor-α–Converting Enzyme Is a Key Regulator of Agonist-Induced Cardiac Hypertrophy and Fibrosis","year":2009,"lang":"en","type":"article","venue":"Hypertension","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Gene knockdown; Fibrosis; Endocrinology; Muscle hypertrophy; Angiotensin II; Internal medicine; Small interfering RNA; Cardiac fibrosis; Myocardial fibrosis; Biology; Medicine; Cancer research; RNA; Receptor; Cell culture; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001299093,0.0002833876,0.0009266089,0.0001403349,0.0001560594,0.00003215285,0.00005938175,0.0001472569,0.00002155591],"category_scores_gemma":[0.0000897628,0.0002217327,0.0004328423,0.0002220718,0.00005842723,0.0001134557,0.0000593213,0.0001997673,0.00001021398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005550663,"about_ca_system_score_gemma":0.0000668633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000177818,"about_ca_topic_score_gemma":4.637236e-7,"domain_scores_codex":[0.998221,0.00004264673,0.0004768084,0.0004903275,0.0004087279,0.0003604559],"domain_scores_gemma":[0.9988028,0.00005755742,0.0001541225,0.0004881866,0.0002544026,0.0002429251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001994243,0.00007379701,0.002425229,0.00008629541,0.00005840954,0.00000996439,0.0002997323,0.000002077053,0.9846121,0.00001967137,0.001440184,0.0107731],"study_design_scores_gemma":[0.001873655,0.0009355837,0.2672768,0.0009281927,0.0004352812,0.0002034332,0.0002220826,0.004263806,0.7203667,0.00005321447,0.002988797,0.0004525222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961687,0.001592837,0.00001278721,0.001151245,0.0002119392,0.0004344625,0.00002557449,0.00007795618,0.0003244416],"genre_scores_gemma":[0.9962755,0.0001875362,0.001537775,0.001619099,0.0002029067,0.000005180411,0.00001469728,0.000039369,0.0001178802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2648516,"threshold_uncertainty_score":0.9041998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02398766250270499,"score_gpt":0.2410860965721673,"score_spread":0.2170984340694623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}