{"id":"W2098574165","doi":"10.1016/s0014-5793(01)02663-1","title":"Mice lacking histidine decarboxylase exhibit abnormal mast cells","year":2001,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":397,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Kanae Foundation for the Promotion of Medical Science; Mochida Memorial Foundation for Medical and Pharmaceutical Research","keywords":"Histidine decarboxylase; Histamine; Histidine; Proteases; Mast cell; Chemistry; Histamine N-methyltransferase; Histamine H4 receptor; Biology; Biochemistry; Cell biology; Molecular biology; Immunology; Enzyme; Histamine H2 receptor; Pharmacology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002819623,0.001336423,0.0004756552,0.001108111,0.0003124034,0.0005943097,0.0004356522,0.001587895,0.003719503],"category_scores_gemma":[0.0004405441,0.0006135452,0.0003967064,0.0004127334,0.0007665699,0.0004221528,0.0004206598,0.001257399,0.001382526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003354451,"about_ca_system_score_gemma":0.0002266437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004311633,"about_ca_topic_score_gemma":0.0005828592,"domain_scores_codex":[0.9995395,0.00004689198,0.00005527582,0.0001624396,0.0001095959,0.00008630976],"domain_scores_gemma":[0.9992359,0.0001261338,0.0003107196,0.00006227734,0.00003909743,0.0002260417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004856618,0.00007946332,0.0006418761,0.00007796272,0.00002121526,0.001253394,0.00005644813,0.0001257917,0.9927728,0.0006765471,0.0004767595,0.003332138],"study_design_scores_gemma":[0.0009276805,0.001837492,0.04310109,0.00009048388,0.0002543057,0.02447526,0.0002035161,0.002302124,0.8933801,0.002046363,0.03127807,0.0001034824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974021,0.003519041,0.01121234,0.0009236199,0.0002185911,0.00009404348,0.004062841,0.001557658,0.004390838],"genre_scores_gemma":[0.9759788,0.002747029,0.007700024,0.0003730705,0.00009137621,0.0001242269,0.002398205,0.0003103979,0.01027689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003719503,"threshold_uncertainty_score":0.01244301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009288454777363033,"score_gpt":0.1981538719377585,"score_spread":0.1888654171603955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}