{"id":"W2098585473","doi":"10.1186/1471-2407-8-318","title":"Role of drug transporters and drug accumulation in the temporal acquisition of drug resistance","year":2008,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Laurentian University; Sudbury Regional Hospital","funders":"Canadian Institutes of Health Research; Cancer Care Ontario; Sanofi","keywords":"Drug; Drug resistance; Pharmacology; Paclitaxel; Abcg2; Epirubicin; Medicine; Docetaxel; Transporter; ATP-binding cassette transporter; Drug interaction; Multiple drug resistance; P-glycoprotein; Chemotherapy; Biology; Cancer; Internal medicine; Breast cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002805199,0.0001173044,0.0002889896,0.00009138019,0.00004695623,0.000002520612,0.0000810114,0.00004158906,0.00005347584],"category_scores_gemma":[0.000003202809,0.00008502161,0.00008362569,0.0002328201,0.0001256236,0.0000940195,0.000003244305,0.0001001603,4.684069e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003571212,"about_ca_system_score_gemma":0.0001225077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007262296,"about_ca_topic_score_gemma":0.009708458,"domain_scores_codex":[0.9989306,0.00004010162,0.0003644809,0.0001882222,0.0003302394,0.000146352],"domain_scores_gemma":[0.999508,0.00003914443,0.000147875,0.0002037515,0.00006153565,0.00003969252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002514876,0.0003151074,0.9158793,0.001146353,0.00004929065,0.00003526284,0.04000038,0.0002156737,0.03663791,0.001086287,0.001347998,0.0007715569],"study_design_scores_gemma":[0.0023751,0.00001951374,0.9657922,0.000572243,0.0001007338,0.000004983998,0.003111033,0.0001138398,0.02542622,0.0005766974,0.001761388,0.0001460426],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946386,0.003405485,0.0001603404,0.0005933736,0.00006500033,0.0003895634,0.00003046097,0.00001422366,0.0007029205],"genre_scores_gemma":[0.9972384,0.000447796,0.0007005237,0.0001022441,0.00005697275,0.00003209559,0.00003800113,0.00001415526,0.001369809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0499129,"threshold_uncertainty_score":0.5417547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02071232850551491,"score_gpt":0.2725177434169712,"score_spread":0.2518054149114562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}