{"id":"W2098597348","doi":"10.1002/jnr.21361","title":"Functional ryanodine receptors are expressed by human microglia and THP‐1 cells: Their possible involvement in modulation of neurotoxicity","year":2007,"lang":"en","type":"article","venue":"Journal of Neuroscience Research","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Fondation pour la Recherche sur Alzheimer","keywords":"Ryanodine receptor; Microglia; Neurotoxicity; Intracellular; Cell biology; Receptor; Calcium in biology; Chemistry; THP1 cell line; Biology; Endocrinology; Internal medicine; Cell culture; Biochemistry; Inflammation; Immunology; Medicine; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003134447,0.0001596474,0.0002458652,0.0009391424,0.0003466438,0.0001344511,0.0004601935,0.00006427495,0.00003177868],"category_scores_gemma":[0.0009113176,0.0001354205,0.00006715015,0.00126205,0.0003748378,0.0006491966,0.0001576865,0.0006351636,0.000002388782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006736362,"about_ca_system_score_gemma":0.00009972803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007492114,"about_ca_topic_score_gemma":0.00001186857,"domain_scores_codex":[0.9961056,0.0006243303,0.0008458027,0.0004592383,0.001510431,0.0004545765],"domain_scores_gemma":[0.9982066,0.0004523551,0.0005469865,0.0002361311,0.0003287544,0.0002291753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001065652,0.0002380532,0.0009953907,0.0000212736,4.155591e-7,0.00003435231,0.0001428999,0.0003464234,0.9966484,0.0002626104,0.0007918685,0.0004117803],"study_design_scores_gemma":[0.000609956,0.0005177375,0.01605629,0.00003586785,0.000001152941,0.00003646583,0.0001018051,0.001573,0.9798513,0.0004642053,0.0006567959,0.00009542893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973151,0.00001958288,0.001133968,0.0006000602,0.0004995758,0.0003370094,0.00001163313,0.00001260235,0.00007044042],"genre_scores_gemma":[0.9989749,0.0001839865,0.00008138047,0.0003525062,0.00007241692,0.0000039797,6.252719e-7,0.00001726875,0.0003129145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01679708,"threshold_uncertainty_score":0.5522287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1490654968755626,"score_gpt":0.3558483519358812,"score_spread":0.2067828550603185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}