{"id":"W2098602111","doi":"10.1128/iai.00033-09","title":"Identification of a Novel Lipopolysaccharide Core Biosynthesis Gene Cluster in <i>Bordetella pertussis</i> , and Influence of Core Structure and Lipid A Glucosamine Substitution on Endotoxic Activity","year":2009,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"","keywords":"Lipid A; Biology; Lipopolysaccharide; Glucosamine; Glycosyltransferase; Oligosaccharide; Gene cluster; Gene; Biosynthesis; Bacterial outer membrane; Bordetella pertussis; Biochemistry; Mutant; Bacteria; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008562415,0.0003452251,0.0003610983,0.0003561253,0.0001788065,0.000355581,0.0002545488,0.0003474498,0.000420792],"category_scores_gemma":[0.0001868105,0.000192169,0.0004773217,0.0002314032,0.0002739869,0.00009636266,0.0002734882,0.000579107,0.0002940951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005337921,"about_ca_system_score_gemma":0.0005313661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00264065,"about_ca_topic_score_gemma":0.00244892,"domain_scores_codex":[0.9998817,0.00001355622,0.00001147356,0.00002604487,0.00003628525,0.00003094158],"domain_scores_gemma":[0.9998302,0.00002928697,0.00005175651,0.00001945919,0.00001987263,0.00004939493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001088596,0.00001674243,0.0003186612,0.00002185795,0.000003814973,0.00006196304,0.00001487511,0.00004021885,0.9987753,0.000028338,0.00001706721,0.0005922704],"study_design_scores_gemma":[0.00006894013,0.0005240667,0.06998742,0.00003791992,0.000138886,0.001813187,0.0002767939,0.002117978,0.9200987,0.0001865535,0.004712005,0.00003745923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956697,0.0004263292,0.002354678,0.0001583016,0.00002791486,0.00003188773,0.0009118867,0.00005233522,0.0003670401],"genre_scores_gemma":[0.9837995,0.0005581709,0.006654247,0.0001503483,0.00001953572,0.00007374721,0.006593547,0.00006887336,0.002082005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00264065,"threshold_uncertainty_score":0.005250573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808683043377832,"score_gpt":0.2588638680085991,"score_spread":0.2407770375748207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}