{"id":"W2098609440","doi":"10.1128/mcb.20.11.3781-3794.2000","title":"Granzyme B Short-Circuits the Need for Caspase 8 Activity during Granule-Mediated Cytotoxic T-Lymphocyte Killing by Directly Cleaving Bid","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":337,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; Alberta Hospital Edmonton; University of Alberta","funders":"","keywords":"Granzyme; Granzyme B; Biology; Cell biology; Granzyme A; Cytotoxic T cell; Perforin; Caspase; Caspase 10; Caspase 7; DNA fragmentation; Cytolysis; Apoptosis; Programmed cell death; Molecular biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002510734,0.0002955973,0.0002603659,0.00004989525,0.0003672272,0.00004151859,0.0001850107,0.0003548827,0.00003185156],"category_scores_gemma":[0.00002504352,0.000233998,0.0001853794,0.0001186343,0.0001437413,0.000006452196,0.00006400813,0.0001194981,0.00000469068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002201215,"about_ca_system_score_gemma":0.00003270763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006920043,"about_ca_topic_score_gemma":0.00001855417,"domain_scores_codex":[0.9984199,0.0001589184,0.0002413662,0.0006084749,0.00009542338,0.0004759177],"domain_scores_gemma":[0.9993622,0.00002875853,0.00006689938,0.0003695893,0.00004828398,0.0001243112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000143754,0.00004451823,0.00007849041,0.00002403679,0.00007088804,0.00001011754,0.00003361809,0.00006022691,0.979081,0.00004929917,0.00003807891,0.02036592],"study_design_scores_gemma":[0.001005015,0.0002353202,0.0001386853,0.00001053181,0.00005873663,0.0000412729,0.00002228183,0.00109458,0.986447,0.0001221515,0.01049488,0.0003295843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764767,0.004861526,0.01758868,0.0001486939,0.0001279774,0.0005496344,0.00006731282,0.0000328896,0.0001466242],"genre_scores_gemma":[0.9973821,0.0009094466,0.0000771886,0.0001963923,0.0001375788,0.00008530759,0.0006548827,0.00004952938,0.0005075558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02090546,"threshold_uncertainty_score":0.9542161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006183867606320237,"score_gpt":0.2135254609613117,"score_spread":0.2073415933549914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}