{"id":"W2098609440","doi":"10.1128/mcb.20.11.3781-3794.2000","title":"Granzyme B Short-Circuits the Need for Caspase 8 Activity during Granule-Mediated Cytotoxic T-Lymphocyte Killing by Directly Cleaving Bid","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":337,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; Alberta Hospital Edmonton; University of Alberta","funders":"","keywords":"Granzyme; Granzyme B; Biology; Cell biology; Granzyme A; Cytotoxic T cell; Perforin; Caspase; Caspase 10; Caspase 7; DNA fragmentation; Cytolysis; Apoptosis; Programmed cell death; Molecular biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001914715,0.0002593411,0.0002423567,0.0001658486,0.000121051,0.0006442413,0.0002101524,0.0003153437,0.0007761421],"category_scores_gemma":[0.0002893677,0.0001601697,0.0002475473,0.0001256232,0.0002474378,0.0005191089,0.0003022469,0.0007451483,0.0003551192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003183105,"about_ca_system_score_gemma":0.0003104643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001986921,"about_ca_topic_score_gemma":0.0002729615,"domain_scores_codex":[0.9998108,0.00003527927,0.0000258423,0.00003583743,0.00005242888,0.00003979597],"domain_scores_gemma":[0.9998053,0.00004264537,0.00005564413,0.00003625107,0.00002285563,0.00003733605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001213037,0.00001596298,0.0001508361,0.00002349622,0.000003835393,0.00004410258,0.00001562826,0.00005009464,0.9988024,0.0001555619,0.00001061606,0.000606209],"study_design_scores_gemma":[0.0000312897,0.0002800761,0.001733131,0.000005058104,0.00001100721,0.0002663032,0.00003390053,0.0008971785,0.9951844,0.0001682269,0.001386176,0.000003274105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947721,0.0009219648,0.003538201,0.00007437434,0.00002430713,0.00001175261,0.00007370715,0.00006591452,0.0005175886],"genre_scores_gemma":[0.9972019,0.0003715985,0.001559706,0.00002876313,0.000006034169,0.00001284495,0.0001145704,0.00001284991,0.0006917382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007761421,"threshold_uncertainty_score":0.002596438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006183867606320237,"score_gpt":0.2135254609613117,"score_spread":0.2073415933549914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}