{"id":"W2098613222","doi":"10.1172/jci43343","title":"Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation","year":2010,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":222,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Ministerio de Educación y Cultura; Cardiff University; University of Oxford","keywords":"C3-convertase; Complement system; Alternative complement pathway; Proteases; Factor H; Mesangium; Pathogenesis; Complement factor I; Proteolysis; Mutant; Chemistry; Cell biology; Biology; Biochemistry; Immunology; Glomerulonephritis; Gene; Endocrinology; Enzyme; Kidney; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001045149,0.0001100579,0.000335737,0.0001520323,0.0001481106,0.00002227513,0.00007687783,0.0001205066,0.00003138553],"category_scores_gemma":[0.001158379,0.00009347912,0.0000790611,0.00007374593,0.0002700724,0.0002934341,0.0000449398,0.0001813201,0.000001398342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001578744,"about_ca_system_score_gemma":0.00008709872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003653076,"about_ca_topic_score_gemma":0.00005183745,"domain_scores_codex":[0.9977214,0.0005072082,0.001409121,0.0001701907,0.0001072555,0.00008479795],"domain_scores_gemma":[0.9974333,0.0004069738,0.001570816,0.000142082,0.0003486085,0.00009820454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001620136,0.0001006402,0.09516051,0.0001357637,0.00008120051,0.00000215524,0.0003495929,0.000006515712,0.8912442,0.008674528,0.0001318151,0.003951021],"study_design_scores_gemma":[0.001401474,0.0003724202,0.859743,0.000299148,0.0001864452,0.00001711514,0.000100415,0.0001358337,0.07186366,0.0657063,0.00007641291,0.00009780574],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970734,0.0003220436,0.00159969,0.0003733019,0.0002642313,0.0003475151,0.000004528584,0.000009773073,0.000005549728],"genre_scores_gemma":[0.9981641,0.00002419312,0.001544358,0.00009457272,0.00009277729,0.00000904737,0.00004195892,0.000008642467,0.00002034362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8193806,"threshold_uncertainty_score":0.3811968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05656454683093461,"score_gpt":0.3484637271839726,"score_spread":0.291899180353038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}