{"id":"W2098623515","doi":"10.1126/scisignal.2003021","title":"Superbinder SH2 Domains Act as Antagonists of Cell Signaling","year":2012,"lang":"en","type":"article","venue":"Science Signaling","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Western University","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Signal transduction; Cell; Chemistry; Biology; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001572435,0.0005311962,0.0002979877,0.0001641496,0.0001221006,0.0002846965,0.0003496347,0.0002968606,0.001558099],"category_scores_gemma":[0.0001163066,0.000126136,0.0002000222,0.0001311583,0.0003253893,0.0002211782,0.0003227431,0.0004856495,0.0004616239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000383985,"about_ca_system_score_gemma":0.0001079017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002599373,"about_ca_topic_score_gemma":0.0004454901,"domain_scores_codex":[0.9998543,0.00002734494,0.000007286608,0.00002916723,0.00005096844,0.00003087253],"domain_scores_gemma":[0.9999106,0.00002429643,0.00002487934,0.000008404361,0.000007492987,0.00002428263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005440388,0.00001131534,0.0001976079,0.00001708347,0.000005694248,0.00003722881,0.000004796716,0.0001455825,0.998714,0.000108181,0.00002550204,0.0006786252],"study_design_scores_gemma":[0.00002505667,0.0001325476,0.002427312,0.000001618769,0.00001090405,0.000245281,0.00001027966,0.001476304,0.9934741,0.00005900357,0.002133523,0.000004124598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991834,0.00121782,0.005535002,0.00004694031,0.00001694072,0.00003041184,0.0001464745,0.00008123819,0.001091227],"genre_scores_gemma":[0.9955799,0.0003053708,0.002489832,0.00004613858,0.000007289706,0.00001745527,0.0002166188,0.00001751442,0.001319927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001558099,"threshold_uncertainty_score":0.005212367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01198656609506473,"score_gpt":0.2677032109894133,"score_spread":0.2557166448943486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}