{"id":"W2098623515","doi":"10.1126/scisignal.2003021","title":"Superbinder SH2 Domains Act as Antagonists of Cell Signaling","year":2012,"lang":"en","type":"article","venue":"Science Signaling","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Western University","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Signal transduction; Cell; Chemistry; Biology; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001433044,0.000190081,0.000177967,0.0001492977,0.0003313715,0.00005423387,0.0003859618,0.0001159288,0.0001384236],"category_scores_gemma":[0.0001354372,0.0001793175,0.0001238684,0.0004580609,0.0004501761,0.00004235366,0.0001552897,0.0001090474,0.00002733628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003371116,"about_ca_system_score_gemma":0.0003377743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002041233,"about_ca_topic_score_gemma":8.620971e-7,"domain_scores_codex":[0.9980614,0.00006268784,0.0003278257,0.0003948605,0.0005207927,0.0006324343],"domain_scores_gemma":[0.9990128,0.00002105766,0.0001615274,0.0003553577,0.0001808882,0.0002683356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002603374,0.00006882278,0.002738466,0.00002466281,0.000007875029,0.000001403715,0.0002338338,0.0004558228,0.9955606,0.000483619,0.00001614669,0.0003827242],"study_design_scores_gemma":[0.000318762,0.00009679203,0.0003683022,0.00003472199,0.00001475959,0.00001636557,0.0002969224,0.0001228911,0.997152,0.0001482444,0.001191563,0.0002387234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919971,0.0009335822,0.004106106,0.00003622722,0.0002150066,0.0001831016,0.000005906804,0.00001974669,0.002503215],"genre_scores_gemma":[0.9946948,0.00001591437,0.004613342,0.0001763481,0.00031528,0.000008372603,0.0000180235,0.00002150076,0.0001363731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002697737,"threshold_uncertainty_score":0.7312357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01198656609506473,"score_gpt":0.2677032109894133,"score_spread":0.2557166448943486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}