{"id":"W2098645858","doi":"10.1128/mcb.25.22.10136-10147.2005","title":"RelB/p52 NF-κB Complexes Rescue an Early Delay in Mammary Gland Development in Transgenic Mice with Targeted Superrepressor IκB-α Expression and Promote Carcinogenesis of the Mammary Gland","year":2005,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Institutes of Health","keywords":"RELB; Biology; Cyclin D1; Mammary gland; Cancer research; LYN; NF-κB; Transcription factor; Mammary tumor; Genetically modified mouse; Molecular biology; Carcinogenesis; Endocrinology; NFKB1; Transgene; Internal medicine; Signal transduction; Cell biology; Cancer; Breast cancer; Cell cycle; Medicine; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002372054,0.0006290282,0.000310567,0.0005394706,0.0001919568,0.0003397052,0.0003015176,0.0003942902,0.002468961],"category_scores_gemma":[0.0001433255,0.0004398515,0.0003965262,0.0001640407,0.0003015611,0.0002518775,0.0002439817,0.001299342,0.001116212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003803581,"about_ca_system_score_gemma":0.0002784751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007159174,"about_ca_topic_score_gemma":0.001001313,"domain_scores_codex":[0.999697,0.00003718405,0.00003832608,0.00008081227,0.00006900233,0.00007763803],"domain_scores_gemma":[0.9996262,0.00002935044,0.0001324355,0.00004238014,0.00002498548,0.0001446231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001084258,0.00003443303,0.00006171156,0.00001413428,0.000002802961,0.00003190547,0.00001102042,0.00001615737,0.9992084,0.0000555249,0.00002240262,0.0004331086],"study_design_scores_gemma":[0.0000454761,0.000473938,0.002766132,0.00001173616,0.00001804082,0.0002314008,0.00003473011,0.0004110928,0.9934914,0.00004675801,0.002464534,0.000004809987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911829,0.001729659,0.003623093,0.0001717029,0.00005917415,0.00005294743,0.001010303,0.0004399041,0.001730259],"genre_scores_gemma":[0.9765564,0.001222098,0.00368921,0.0001021316,0.00002556904,0.0001274677,0.001917916,0.0002166297,0.01614247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002468961,"threshold_uncertainty_score":0.008259535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00782189879684858,"score_gpt":0.2044855393586682,"score_spread":0.1966636405618196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}