{"id":"W2098645858","doi":"10.1128/mcb.25.22.10136-10147.2005","title":"RelB/p52 NF-κB Complexes Rescue an Early Delay in Mammary Gland Development in Transgenic Mice with Targeted Superrepressor IκB-α Expression and Promote Carcinogenesis of the Mammary Gland","year":2005,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Institutes of Health","keywords":"RELB; Biology; Cyclin D1; Mammary gland; Cancer research; LYN; NF-κB; Transcription factor; Mammary tumor; Genetically modified mouse; Molecular biology; Carcinogenesis; Endocrinology; NFKB1; Transgene; Internal medicine; Signal transduction; Cell biology; Cancer; Breast cancer; Cell cycle; Medicine; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003203758,0.0002801577,0.0003257573,0.000106069,0.00007728722,0.00001910318,0.0003209152,0.0003069746,0.000002864134],"category_scores_gemma":[0.00001712354,0.0002086246,0.00005413391,0.0001474531,0.0001693188,0.00001380443,0.0002019221,0.0001678093,3.156851e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001606984,"about_ca_system_score_gemma":0.0001130155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001951172,"about_ca_topic_score_gemma":0.0007961486,"domain_scores_codex":[0.9980729,0.000388148,0.0003892677,0.0006632826,0.0001196662,0.0003667058],"domain_scores_gemma":[0.999276,0.00001256891,0.00008140376,0.0004788482,0.00005158344,0.00009955859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002399169,0.0000959813,0.05333966,0.00004554603,0.00003887829,0.00002822468,0.0004875423,0.00007088484,0.9445778,0.00004385208,0.000003457553,0.001028314],"study_design_scores_gemma":[0.001647107,0.0003406185,0.02319147,0.00005882368,0.00001850715,0.00004519938,0.00002894778,0.0001034616,0.9733198,0.00005008935,0.0009085686,0.0002874701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898967,0.005669593,0.003796187,0.0001165047,0.00003145641,0.0004266713,0.00002001693,0.000009950607,0.00003295354],"genre_scores_gemma":[0.995096,0.000128894,0.004371463,0.0001086084,0.00002845219,0.00004182417,0.0001643536,0.000030235,0.00003016807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0301482,"threshold_uncertainty_score":0.8507463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00782189879684858,"score_gpt":0.2044855393586682,"score_spread":0.1966636405618196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}