{"id":"W2098661636","doi":"10.1016/s1701-2163(15)31025-2","title":"RETIRED: Current Status in Non-Invasive Prenatal Detection of Down Syndrome, Trisomy 18, and Trisomy 13 Using Cell-Free DNA in Maternal Plasma","year":2013,"lang":"en","type":"article","venue":"Journal of Obstetrics and Gynaecology Canada","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":false,"ca_institutions":"Cochrane; Congress of Aboriginal Peoples; Moncton Hospital; Ontario Neurotrauma Foundation; Alberta Bible College","funders":"","keywords":"Medicine; Guideline; Trisomy; Cell-free fetal DNA; Down syndrome; Randomized controlled trial; Specialty; Prenatal diagnosis; Family medicine; Clinical trial; Clinical Practice; Pediatrics; Pregnancy; Pathology; Fetus; Psychiatry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001908079,0.0001543607,0.0005232606,0.0005905189,0.00003828204,0.00001941177,0.0001048805,0.0001444599,0.00004527661],"category_scores_gemma":[0.003509667,0.0001337298,0.00004075439,0.0003961223,0.00007016878,0.0001440911,0.00008806149,0.000498808,2.122317e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006732192,"about_ca_system_score_gemma":0.0009527498,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.07266755,"about_ca_topic_score_gemma":0.03703416,"domain_scores_codex":[0.99843,0.00006266949,0.0007092478,0.0001597281,0.000311184,0.0003272449],"domain_scores_gemma":[0.9972226,0.001690291,0.0004888522,0.0001234661,0.0001945022,0.0002802642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005556877,0.0001556806,0.9414732,0.0003295264,0.00004555681,0.002794169,0.0001196874,0.0002066295,0.000620742,0.000001959448,0.0002329834,0.05396426],"study_design_scores_gemma":[0.008298882,0.0008196381,0.9832171,0.0001469326,0.00007664133,0.0004574799,0.0002697924,0.001733435,0.004682545,0.00005709112,0.0001087135,0.0001318153],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932079,0.004364683,0.00003907766,0.00004499156,0.001929766,0.0002621617,0.00003482102,0.000001702358,0.0001148399],"genre_scores_gemma":[0.9988661,0.0006863328,0.0003766712,0.00002413431,0.00001693018,0.00000396093,0.000003036443,0.00001110894,0.00001174944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05383245,"threshold_uncertainty_score":0.9805375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01110023450144815,"score_gpt":0.2250558278634985,"score_spread":0.2139555933620503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}