{"id":"W2098697412","doi":"10.1093/hmg/ddt327","title":"Mitochondrial DNA deletions in muscle satellite cells: implications for therapies","year":2013,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Wellcome Trust Centre for Mitochondrial Research; NIHR Newcastle Biomedical Research Centre; Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; Research Councils UK; Engineering and Physical Sciences Research Council; National Institute for Health and Care Research; Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu; Newcastle University; Wellcome Trust","keywords":"Heteroplasmy; Mitochondrial DNA; Biology; Satellite; Mitochondrial myopathy; Mutation; Genetics; Myocyte; Myopathy; Mitochondrion; Molecular biology; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006368406,0.0001892748,0.0001551104,0.00009057021,0.0001321087,0.00005007494,0.0002271618,0.000222352,0.0001026338],"category_scores_gemma":[0.00003039204,0.0002035331,0.000145249,0.0001057032,0.00008968451,0.000003595409,0.00006302444,0.00008594109,0.00005271269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001413488,"about_ca_system_score_gemma":0.00004285841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001842861,"about_ca_topic_score_gemma":0.00009963901,"domain_scores_codex":[0.9987639,0.00009035553,0.0003079728,0.0004414518,0.0000698132,0.0003265118],"domain_scores_gemma":[0.9991216,0.00001633799,0.00007492227,0.0005439611,0.0001477441,0.00009541785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001082063,0.00007054318,0.0003992436,0.000007476172,0.00001995418,6.338042e-7,0.00006427718,0.0001148041,0.993537,0.001135647,0.00267769,0.001961895],"study_design_scores_gemma":[0.002182363,0.0006990083,0.05642679,0.00001272306,0.00004899519,0.00001300218,0.0001370717,0.00005587807,0.5696425,0.009376287,0.3607118,0.000693637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9492884,0.001496739,0.04577853,0.0005059391,0.0004701746,0.001155796,0.00004142729,0.00002620506,0.00123678],"genre_scores_gemma":[0.9728882,0.0004671973,0.02218044,0.001301017,0.0005915771,0.0008954679,0.0005589541,0.00007950428,0.001037596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4238945,"threshold_uncertainty_score":0.8299838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01893667565574495,"score_gpt":0.2688051006412121,"score_spread":0.2498684249854672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}