{"id":"W2098697412","doi":"10.1093/hmg/ddt327","title":"Mitochondrial DNA deletions in muscle satellite cells: implications for therapies","year":2013,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Wellcome Trust Centre for Mitochondrial Research; NIHR Newcastle Biomedical Research Centre; Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; Research Councils UK; Engineering and Physical Sciences Research Council; National Institute for Health and Care Research; Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu; Newcastle University; Wellcome Trust","keywords":"Heteroplasmy; Mitochondrial DNA; Biology; Satellite; Mitochondrial myopathy; Mutation; Genetics; Myocyte; Myopathy; Mitochondrion; Molecular biology; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001473842,0.0005092849,0.0007537651,0.0007765515,0.0004037107,0.001196474,0.0009551042,0.002407394,0.004372042],"category_scores_gemma":[0.001569848,0.0001748715,0.0003604548,0.0003605436,0.001141553,0.00122431,0.0006759923,0.001869264,0.001152337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006500788,"about_ca_system_score_gemma":0.0008643981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002889544,"about_ca_topic_score_gemma":0.0007987037,"domain_scores_codex":[0.9996625,0.0001385142,0.00002821689,0.00003522876,0.00009041504,0.00004506256],"domain_scores_gemma":[0.9992725,0.0003828491,0.000101638,0.00005340426,0.00009771124,0.00009195023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002466053,0.002261524,0.005640026,0.004538254,0.0001541438,0.005432074,0.0007906143,0.002765386,0.04811881,0.04303044,0.03183153,0.8529711],"study_design_scores_gemma":[0.002331512,0.01045767,0.01650485,0.007046205,0.000457315,0.01773931,0.001760324,0.003842241,0.03013698,0.09619961,0.8133618,0.0001622618],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.04508807,0.8124219,0.008630875,0.1001485,0.0025873,0.000171008,0.0001955703,0.0001614494,0.03059525],"genre_scores_gemma":[0.2834941,0.6564583,0.0173353,0.02248573,0.006444396,0.000525118,0.0002385191,0.00006846184,0.01295004],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004372042,"threshold_uncertainty_score":0.01462591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01893667565574495,"score_gpt":0.2688051006412121,"score_spread":0.2498684249854672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}