{"id":"W2098714535","doi":"10.1042/bj20081869","title":"Trafficking of immature ΔF508-CFTR to the plasma membrane and its detection by biotinylation","year":2008,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Cystic Fibrosis Foundation Therapeutics; Cystic Fibrosis Foundation","keywords":"Biotinylation; Biotin; Baby hamster kidney cell; Chemistry; Biochemistry; Streptavidin; Cystic fibrosis transmembrane conductance regulator; Intracellular; ΔF508; Molecular biology; Biology; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001818369,0.00008169444,0.000147127,0.00007345869,0.0001197632,0.00001400305,0.0000718462,0.00007606519,0.00002764684],"category_scores_gemma":[0.0006156808,0.00005174255,0.00004881589,0.0002093974,0.00006298452,0.00005696098,0.00002665996,0.0003354842,0.000005308286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004403416,"about_ca_system_score_gemma":0.0000360788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002054003,"about_ca_topic_score_gemma":8.370178e-7,"domain_scores_codex":[0.9990696,0.00002943317,0.0002146701,0.0001188735,0.0003937444,0.0001736941],"domain_scores_gemma":[0.9994222,0.00009859604,0.00007755438,0.00007763152,0.0001317478,0.0001922513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005538259,0.00003238393,0.00009643939,0.00003329125,0.00001935763,0.000007585962,0.0001503565,0.000009774286,0.9902145,0.000001471744,0.002105208,0.006775829],"study_design_scores_gemma":[0.0006619465,0.0002285166,0.003444025,0.00009763968,0.00001745226,0.001745369,0.0000598243,0.001007451,0.9890494,0.000004407646,0.003628731,0.00005527892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955547,0.001978209,0.0005092653,0.001655307,0.00007343815,0.0001587274,0.000007207728,0.00001202412,0.00005107269],"genre_scores_gemma":[0.9983957,0.0002707334,0.0009342526,0.00005896451,0.0002539982,0.000002146125,0.000004091841,0.000009352326,0.00007080146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006720551,"threshold_uncertainty_score":0.211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01305059074870869,"score_gpt":0.2709060664376272,"score_spread":0.2578554756889185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}