{"id":"W2098756782","doi":"10.1074/jbc.m207753200","title":"Differential Partitioning of Lipids Metabolized by Separate Yeast Glycerol-3-phosphate Acyltransferases Reveals That Phospholipase D Generation of Phosphatidic Acid Mediates Sensitivity to Choline-containing Lysolipids and Drugs","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Izaak Walton Killam Health Centre; Dalhousie University","funders":"","keywords":"Phosphatidic acid; Yeast; Biochemistry; Phospholipase D; Phosphatidylcholine; Phospholipid; Saccharomyces cerevisiae; Phospholipase; Biology; Phosphatidylethanol; PLD2; Choline; Chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008212864,0.0004655347,0.0002701021,0.000286318,0.0001220009,0.0004203804,0.0001453697,0.0002471855,0.0007015153],"category_scores_gemma":[0.0001104433,0.0001877915,0.0002988788,0.0001750292,0.0001621251,0.0002235664,0.0003360504,0.0004716961,0.0002567579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002926234,"about_ca_system_score_gemma":0.0001446762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001108184,"about_ca_topic_score_gemma":0.000965547,"domain_scores_codex":[0.9999011,0.00001044939,0.0000133665,0.00002730987,0.00002795164,0.00001998248],"domain_scores_gemma":[0.9998988,0.00001949497,0.00003020796,0.00001515832,0.00001350177,0.00002295347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001104924,0.000005263916,0.000466095,0.00001214275,0.000002773053,0.0000304489,0.000008461653,0.00003102529,0.9986097,0.00001948454,0.000004280341,0.0006999407],"study_design_scores_gemma":[0.0000105969,0.0001234586,0.007573859,0.000003061819,0.00001421232,0.0003195846,0.00004003731,0.000637401,0.9904985,0.00003706022,0.0007358516,0.000006343776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969345,0.0005175506,0.001729495,0.00004627672,0.000008417761,0.00001546156,0.000386551,0.00003623669,0.0003255174],"genre_scores_gemma":[0.994912,0.0006231348,0.002628378,0.00004585137,0.000003053094,0.00001941321,0.0008806683,0.00002851378,0.0008589228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001108184,"threshold_uncertainty_score":0.002346814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02618439326062053,"score_gpt":0.2439985735380589,"score_spread":0.2178141802774384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}