{"id":"W2098758088","doi":"10.1093/brain/awl289","title":"Mutations in progranulin explain atypical phenotypes with variants in MAPT","year":2006,"lang":"en","type":"letter","venue":"Brain","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Vancouver Coastal Health","funders":"National Institute on Aging","keywords":"Frontotemporal dementia; Tauopathy; PSEN1; Presenilin; Tau protein; Phenotype; C9orf72; Frontotemporal lobar degeneration; Mutation; Genetics; Biology; Dementia; Alzheimer's disease; Disease; Pathology; Medicine; Neurodegeneration; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0003359876,0.0003094192,0.0005835188,0.0005147404,0.00003491464,0.00004428185,0.0002036794,0.0006928983,0.000490101],"category_scores_gemma":[0.000150373,0.0002371196,0.00007140984,0.0006814275,0.0001772462,0.0000777628,0.00005752081,0.002331214,0.0002072561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000315483,"about_ca_system_score_gemma":0.0003040816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009535524,"about_ca_topic_score_gemma":0.001198294,"domain_scores_codex":[0.9972516,0.0002776155,0.0004593404,0.0005835845,0.0006999557,0.0007278468],"domain_scores_gemma":[0.9990938,0.000282085,0.00007752305,0.0003958351,0.00006279118,0.00008794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0005461011,0.0003659381,0.01972081,0.0003439118,0.0000534164,0.008567863,0.0003507684,0.00003822909,0.0002913754,0.000068519,0.9645936,0.005059401],"study_design_scores_gemma":[0.005654447,0.0005081205,0.7443542,0.001434393,0.00003706586,0.00009860007,0.00002834678,0.0003895183,0.00001348137,0.0007898423,0.2461753,0.0005167088],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1172689,0.00011695,0.0001306818,0.8779488,0.00007421071,0.001892336,0.00003571726,0.00008012441,0.002452248],"genre_scores_gemma":[0.3877343,0.00002262789,0.01078613,0.5510927,0.004033088,0.001556193,0.00474837,0.0004075339,0.03961902],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.7246333,"threshold_uncertainty_score":0.9999704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0243540899043108,"score_gpt":0.2870767577214893,"score_spread":0.2627226678171785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}