{"id":"W2098783855","doi":"10.4049/jimmunol.0901814","title":"TLR9 Blockade Inhibits Activation of Diabetogenic CD8+ T Cells and Delays Autoimmune Diabetes","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Calgary; Child and Family Research Institute; SKiN Health; University of British Columbia","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Juvenile Diabetes Research Foundation International","keywords":"NOD mice; TLR9; Nod; CD8; T cell; Cytotoxic T cell; Agonist; CpG Oligodeoxynucleotide; Biology; Endocrinology; Immunology; Chemistry; Immune system; Internal medicine; Receptor; Medicine; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001211219,0.000355778,0.0003571223,0.0001185038,0.00008097598,0.0001887713,0.0001890828,0.0002687,0.001156169],"category_scores_gemma":[0.0001449682,0.0001226955,0.0001690772,0.00006376775,0.0001491,0.0001648487,0.0001290763,0.0008043139,0.0004012729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001383664,"about_ca_system_score_gemma":0.0001754231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001605761,"about_ca_topic_score_gemma":0.0003636648,"domain_scores_codex":[0.9998224,0.00003889424,0.00002318925,0.00002644696,0.00002788807,0.0000610699],"domain_scores_gemma":[0.9998491,0.00002844513,0.0000446871,0.00001570847,0.00001030132,0.00005180908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007549366,0.0001960246,0.0001509386,0.00004735466,0.000006528194,0.00003546393,0.000006169375,0.0000716799,0.9966748,0.00004609339,0.00004663521,0.001963333],"study_design_scores_gemma":[0.0001644779,0.003729462,0.00270913,0.00001099355,0.00002530171,0.0002988667,0.0000192847,0.0008198019,0.9906465,0.00004318487,0.001527893,0.000005085236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996461,0.001094047,0.0008383946,0.00008623525,0.00004568748,0.00002718753,0.0001612484,0.00008030815,0.0012059],"genre_scores_gemma":[0.9952294,0.0009488717,0.001264468,0.00009144851,0.00002487667,0.0000513909,0.0004002568,0.0000197524,0.001969586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001156169,"threshold_uncertainty_score":0.003867805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0033599680029822,"score_gpt":0.1953187669890116,"score_spread":0.1919587989860294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}