{"id":"W2098783855","doi":"10.4049/jimmunol.0901814","title":"TLR9 Blockade Inhibits Activation of Diabetogenic CD8+ T Cells and Delays Autoimmune Diabetes","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Calgary; Child and Family Research Institute; SKiN Health; University of British Columbia","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Juvenile Diabetes Research Foundation International","keywords":"NOD mice; TLR9; Nod; CD8; T cell; Cytotoxic T cell; Agonist; CpG Oligodeoxynucleotide; Biology; Endocrinology; Immunology; Chemistry; Immune system; Internal medicine; Receptor; Medicine; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004517075,0.0001085972,0.0002106498,0.00005867023,0.0000647178,0.000008255785,0.0002337739,0.0001788949,0.00001775967],"category_scores_gemma":[0.0001343645,0.00007727525,0.0000849377,0.00007804378,0.0002092742,0.000008089672,0.0001029903,0.0002901863,0.000001615011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004984061,"about_ca_system_score_gemma":0.00005691869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008875903,"about_ca_topic_score_gemma":0.000005586004,"domain_scores_codex":[0.9992124,0.00009985944,0.0003254058,0.00007918957,0.00008138829,0.0002017977],"domain_scores_gemma":[0.9991153,0.00006658126,0.0004550459,0.0001902091,0.0001461942,0.00002661861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005232961,0.00004840789,0.002200254,0.000005696436,0.0002484279,1.539924e-7,0.00009868807,0.00001947638,0.993832,0.00002207755,0.0001754014,0.003297108],"study_design_scores_gemma":[0.00070035,0.0004511223,0.0103746,0.00001584115,0.0000625064,0.000008433317,0.0001475959,0.00001705794,0.9855632,0.0002290089,0.002345784,0.00008447645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996787,0.002348918,0.00002524949,0.0004016896,0.0002544682,0.00006253948,0.000005322546,0.000002583692,0.0001122649],"genre_scores_gemma":[0.9988096,0.0008331517,0.00009978494,0.00009863365,0.00006829712,0.000001113109,0.000005724131,0.00001321801,0.00007046509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008268757,"threshold_uncertainty_score":0.3151193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0033599680029822,"score_gpt":0.1953187669890116,"score_spread":0.1919587989860294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}