{"id":"W2098823639","doi":"10.1039/c4tx00114a","title":"Effects of benzo[a]pyrene on mouse germ cells: heritable DNA mutation, testicular cell hypomethylation and their interaction with nucleotide excision repair","year":2015,"lang":"en","type":"article","venue":"Toxicology Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada; European Chemical Industry Council","keywords":"Benzo(a)pyrene; Nucleotide excision repair; Mutation; Biology; DNA repair; Genetics; DNA; Germ; Germ cell; Nucleotide; Pyrene; Molecular biology; Cancer research; Carcinogen; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001083154,0.0001471126,0.0001820712,0.0001910209,0.0001061374,0.00002272358,0.0001066806,0.0002099895,0.000007148596],"category_scores_gemma":[0.0005170153,0.0001187818,0.00003927736,0.0002246757,0.000174001,0.0000124299,0.0001026314,0.000201631,0.00000903931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004559322,"about_ca_system_score_gemma":0.0001152122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004712368,"about_ca_topic_score_gemma":0.00003793851,"domain_scores_codex":[0.9983641,0.0004731382,0.000226363,0.0003992736,0.0002573007,0.0002798462],"domain_scores_gemma":[0.9986202,0.000339912,0.0001106901,0.0002999401,0.0004844253,0.0001448994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004142698,0.000248633,0.0007362022,0.00006146404,0.00003054287,0.000007418311,0.0002291864,0.0009955243,0.9950973,0.00002227359,0.0002427485,0.001914461],"study_design_scores_gemma":[0.0009611728,0.004565545,0.002405806,0.00002006353,0.00001204191,0.000003659637,0.0002298569,0.0007945763,0.9892182,0.0003231258,0.001343193,0.0001228034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964523,0.001117192,0.001048583,0.00006324984,0.00007660455,0.0004627388,0.000005120355,0.0000184194,0.0007557825],"genre_scores_gemma":[0.9978464,0.0002281267,0.001203347,0.00002650605,0.00008517486,0.00004307419,0.00004793787,0.00002944884,0.0004899509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00587912,"threshold_uncertainty_score":0.4843782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03263422023047198,"score_gpt":0.3138334029540998,"score_spread":0.2811991827236279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}