{"id":"W2098823639","doi":"10.1039/c4tx00114a","title":"Effects of benzo[a]pyrene on mouse germ cells: heritable DNA mutation, testicular cell hypomethylation and their interaction with nucleotide excision repair","year":2015,"lang":"en","type":"article","venue":"Toxicology Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada; European Chemical Industry Council","keywords":"Benzo(a)pyrene; Nucleotide excision repair; Mutation; Biology; DNA repair; Genetics; DNA; Germ; Germ cell; Nucleotide; Pyrene; Molecular biology; Cancer research; Carcinogen; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791135,0.0003256258,0.0001324594,0.0003525779,0.0001408909,0.0001638619,0.0001944666,0.0003119302,0.002489028],"category_scores_gemma":[0.0001233411,0.0002465559,0.0002278101,0.0001851567,0.0002306769,0.0001233466,0.000153209,0.0003629138,0.0003740939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002098287,"about_ca_system_score_gemma":0.0001743971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001158768,"about_ca_topic_score_gemma":0.002004612,"domain_scores_codex":[0.9998239,0.00004203271,0.00001472514,0.00003669372,0.00004552576,0.00003710276],"domain_scores_gemma":[0.9997986,0.00004559678,0.00006372845,0.00002299402,0.00001327701,0.00005588515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001535747,0.00002012734,0.000306574,0.0000200016,0.000007177582,0.00003005166,0.000008848689,0.00002497774,0.9987642,0.00005799579,0.0000234273,0.0005831611],"study_design_scores_gemma":[0.00001025163,0.0003130478,0.009462077,0.000003379399,0.00001567847,0.00009671361,0.00001544008,0.00009864934,0.98917,0.00003072358,0.0007808019,0.000003193317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911979,0.002448617,0.002987262,0.0001439853,0.00003950401,0.00003771412,0.0009919425,0.0001355305,0.002017612],"genre_scores_gemma":[0.9915465,0.001487139,0.001080055,0.00006584148,0.00001015616,0.00003384087,0.0006686099,0.00002180162,0.005086111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002489028,"threshold_uncertainty_score":0.00832665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03263422023047198,"score_gpt":0.3138334029540998,"score_spread":0.2811991827236279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}