{"id":"W2098837411","doi":"10.1093/abbs/40.8.711","title":"Simultaneous knockdown of p18<sup>INK4C</sup>, p27<sup>Kip1</sup> and MAD1 via RNA interference results in the expansion of long-term culture-initiating cells of murine bone marrow cells <italic>in vitro</italic>","year":2008,"lang":"en","type":"article","venue":"Acta Biochimica et Biophysica Sinica","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Gene knockdown; Haematopoiesis; RNA interference; Stem cell; Biology; Cell biology; Cell cycle; Small hairpin RNA; Molecular biology; Cell culture; Chemistry; Cell; RNA; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001002007,0.000458088,0.0002712066,0.0002480392,0.0001508325,0.0002794365,0.0002789342,0.0002086576,0.002238756],"category_scores_gemma":[0.00007914506,0.0001591665,0.0003189751,0.0002161344,0.0003225337,0.0002513049,0.0002270172,0.0008361652,0.0008196837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002865299,"about_ca_system_score_gemma":0.0002717447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005488003,"about_ca_topic_score_gemma":0.0009950768,"domain_scores_codex":[0.9998206,0.00001220702,0.0000283203,0.00005860212,0.00004574731,0.00003448854],"domain_scores_gemma":[0.9998764,0.00002055548,0.00003444783,0.00001912597,0.000009371059,0.00004005583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006357991,0.00001742063,0.0001261703,0.00003143455,0.00000453647,0.00004366354,0.000009764587,0.00006652113,0.9980209,0.0002329245,0.00008530501,0.001297794],"study_design_scores_gemma":[0.000006817872,0.00006229874,0.001300439,0.000001861689,0.000008752768,0.00008474632,0.000009711187,0.0006085579,0.9946021,0.00002734475,0.003284805,0.000002432815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9723984,0.001512517,0.01544931,0.00016809,0.0001582153,0.00007814504,0.00325885,0.0005636815,0.006412745],"genre_scores_gemma":[0.9692994,0.001096568,0.01113375,0.0001008773,0.00002669997,0.0001564648,0.003706327,0.0001632209,0.01431672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002238756,"threshold_uncertainty_score":0.007489383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02927758813154304,"score_gpt":0.2812599698435637,"score_spread":0.2519823817120206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}