{"id":"W2098837411","doi":"10.1093/abbs/40.8.711","title":"Simultaneous knockdown of p18<sup>INK4C</sup>, p27<sup>Kip1</sup> and MAD1 via RNA interference results in the expansion of long-term culture-initiating cells of murine bone marrow cells <italic>in vitro</italic>","year":2008,"lang":"en","type":"article","venue":"Acta Biochimica et Biophysica Sinica","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Gene knockdown; Haematopoiesis; RNA interference; Stem cell; Biology; Cell biology; Cell cycle; Small hairpin RNA; Molecular biology; Cell culture; Chemistry; Cell; RNA; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"category_scores_codex":[0.005461751,0.006339889,0.009521012,0.003512218,0.001477268,0.0006882722,0.005275303,0.003978815,0.001519865],"category_scores_gemma":[0.00485712,0.005758897,0.003246188,0.00649935,0.004740673,0.00191635,0.00216385,0.005372044,0.002230369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001208926,"about_ca_system_score_gemma":0.001383034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001088755,"about_ca_topic_score_gemma":0.005555724,"domain_scores_codex":[0.9631168,0.004023656,0.01265244,0.007521315,0.006689842,0.005995982],"domain_scores_gemma":[0.9672601,0.0089087,0.007299689,0.01090764,0.002978818,0.002645085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009792137,0.007474635,0.0006772187,0.00452201,0.001558847,0.0002321402,0.03530805,0.0008744589,0.9257686,0.0001068195,0.01126796,0.002417099],"study_design_scores_gemma":[0.06001803,0.005710788,0.01075094,0.03541497,0.01179499,0.008014502,0.001822544,0.001184912,0.589501,0.001088256,0.2528182,0.02188081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9681252,0.003815028,0.003817616,0.002595701,0.001464962,0.007628082,0.006688396,0.0009934527,0.004871611],"genre_scores_gemma":[0.9255496,0.006976976,0.03986822,0.001311998,0.001477342,0.0005561703,0.01566224,0.001216425,0.00738108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3362676,"threshold_uncertainty_score":0.9998227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02927758813154304,"score_gpt":0.2812599698435637,"score_spread":0.2519823817120206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}