{"id":"W2098844349","doi":"10.1158/1078-0432.ccr-05-2352","title":"ErbB Receptor Signaling and Therapeutic Resistance to Aromatase Inhibitors","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Aromatase; Coactivator; Estrogen receptor; Letrozole; Chromatin immunoprecipitation; Cancer research; Androstenedione; Biology; Aromatase inhibitor; Endocrinology; Promoter; Internal medicine; Molecular biology; Transcription factor; Cancer; Gene expression; Gene; Breast cancer; Medicine; Androgen; Biochemistry; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001423469,0.0001130149,0.0001579349,0.00005428269,0.0001602312,0.0000428718,0.0001732027,0.0002391062,0.00003048612],"category_scores_gemma":[0.0001991873,0.00009503387,0.00007349811,0.0002202953,0.00025416,0.000002323268,0.0001488366,0.0003982419,0.00005035522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002448352,"about_ca_system_score_gemma":0.0001307031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008531247,"about_ca_topic_score_gemma":0.00007485048,"domain_scores_codex":[0.9981973,0.0003535366,0.0003042526,0.0004866039,0.0002668639,0.0003914358],"domain_scores_gemma":[0.9991776,0.0001592016,0.00003816545,0.0002931223,0.0001281279,0.0002038117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009883509,0.0001422795,0.01104908,0.00004362153,0.00006457422,0.00001384967,0.00002546124,0.00003792584,0.8942732,0.0002153103,0.08411315,0.00903323],"study_design_scores_gemma":[0.001348427,0.001060566,0.006603444,0.0001558025,0.00002152975,0.00000310784,0.00006868585,0.00001575621,0.6257511,0.0006913114,0.3639051,0.0003751585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850413,0.01248038,0.00002332999,0.001279826,0.0001742173,0.00031113,0.00002254169,0.00001340384,0.0006539393],"genre_scores_gemma":[0.9952744,0.000837805,0.0002657934,0.0002699296,0.0009851615,0.00005240418,0.00003388529,0.00002685407,0.002253819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.279792,"threshold_uncertainty_score":0.3875369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05557766471763231,"score_gpt":0.4305431315087353,"score_spread":0.374965466791103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}