{"id":"W2098844349","doi":"10.1158/1078-0432.ccr-05-2352","title":"ErbB Receptor Signaling and Therapeutic Resistance to Aromatase Inhibitors","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Aromatase; Coactivator; Estrogen receptor; Letrozole; Chromatin immunoprecipitation; Cancer research; Androstenedione; Biology; Aromatase inhibitor; Endocrinology; Promoter; Internal medicine; Molecular biology; Transcription factor; Cancer; Gene expression; Gene; Breast cancer; Medicine; Androgen; Biochemistry; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002473173,0.0001819926,0.0002916027,0.0001347412,0.00009245366,0.0003377889,0.0001425431,0.0002249243,0.001457409],"category_scores_gemma":[0.000277428,0.00009660149,0.0001470488,0.0001337882,0.0001609566,0.000156896,0.00008762967,0.0004129945,0.0002407255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00024767,"about_ca_system_score_gemma":0.0001079885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002944503,"about_ca_topic_score_gemma":0.000638139,"domain_scores_codex":[0.9998304,0.00004683357,0.00001094927,0.00001494529,0.00004784353,0.00004903358],"domain_scores_gemma":[0.9999102,0.00003213723,0.00002257472,0.000009675664,0.000009865238,0.00001555647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005783783,0.0001430057,0.002021848,0.00004547666,0.00002293548,0.0002680161,0.000034964,0.000293807,0.9891143,0.0002995281,0.0001787573,0.006998909],"study_design_scores_gemma":[0.000119453,0.00398674,0.02546471,0.00001416645,0.00008651319,0.002903835,0.0001192921,0.001770703,0.9550812,0.0002055587,0.01023532,0.00001256191],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939635,0.003748684,0.0003702847,0.000153615,0.00001127783,0.00001341273,0.0001083404,0.00002787483,0.001603097],"genre_scores_gemma":[0.9974893,0.001327692,0.0001463412,0.0000294301,0.00000563458,0.000006959848,0.0001647248,0.000004025846,0.0008259131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001457409,"threshold_uncertainty_score":0.004875541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05557766471763231,"score_gpt":0.4305431315087353,"score_spread":0.374965466791103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}