{"id":"W2098930740","doi":"10.1111/j.1365-2958.2005.04914.x","title":"A proteomic analysis of penicillin resistance in <i>Streptococcus pneumoniae</i> reveals a novel role for PstS, a subunit of the phosphate ABC transporter","year":2005,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université Laval","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research","keywords":"Biology; ATP-binding cassette transporter; Streptococcus pneumoniae; Microbiology; Operon; Penicillin; Mutant; Gene; Transporter; Phenotype; Bacteria; Protein subunit; Gene expression; Genetics; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002269018,0.0001606864,0.0006233864,0.0002548001,0.00003743514,0.000002222949,0.0001657873,0.000171799,0.00002569436],"category_scores_gemma":[0.0000382753,0.0001179192,0.0004747132,0.0007591845,0.000177051,0.00001969296,0.0000205893,0.0001659425,0.00000164934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005619532,"about_ca_system_score_gemma":0.0001055695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002780151,"about_ca_topic_score_gemma":0.0004710254,"domain_scores_codex":[0.9987195,0.00007125917,0.0005996673,0.000290766,0.00005403033,0.000264798],"domain_scores_gemma":[0.9990839,0.00003505127,0.0002626447,0.0004499595,0.0001275878,0.00004083696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001121342,0.0002700126,0.03282849,0.00007664234,0.0004523924,0.000003674311,0.0002353791,0.0003209093,0.9655199,0.00009128197,0.00002009085,0.00006907325],"study_design_scores_gemma":[0.002367101,0.0001826033,0.07349761,0.0001404578,0.001314654,0.00001568826,0.00002468386,0.0001082087,0.9097586,0.00004195608,0.01238131,0.00016716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957042,0.0004476018,0.000936258,0.001171175,0.00003167523,0.00129781,0.0002704161,0.00001161957,0.0001292399],"genre_scores_gemma":[0.9984114,0.0000154873,0.0003557759,0.0007413719,0.00001276081,0.0001814421,0.00004561655,0.00001786019,0.0002182643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05576135,"threshold_uncertainty_score":0.4808605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007481514160792874,"score_gpt":0.2434721597281533,"score_spread":0.2359906455673604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}