{"id":"W2098934646","doi":"10.2337/diabetes.54.2.482","title":"β-Cell <i>Pdx1</i> Expression Is Essential for the Glucoregulatory, Proliferative, and Cytoprotective Actions of Glucagon-Like Peptide-1","year":2005,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":243,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"","keywords":"PDX1; Endocrinology; Internal medicine; Proglucagon; Insulin; Islet; Amylin; Glucagon-like peptide-1; Glucagon; Biology; Glucagon-like peptide 1 receptor; Insulin oscillation; Alpha cell; Receptor; Chemistry; Agonist; Beta cell; Diabetes mellitus; Medicine; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001061234,0.0003604197,0.0001914026,0.0001651618,0.0001863437,0.0005033097,0.0001905516,0.000182007,0.001749934],"category_scores_gemma":[0.0001111223,0.0001737594,0.0001460328,0.00008461611,0.0002635095,0.0001862288,0.000199095,0.0007184946,0.0005039112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002193216,"about_ca_system_score_gemma":0.0001530042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003024891,"about_ca_topic_score_gemma":0.0003698238,"domain_scores_codex":[0.9998907,0.00001235149,0.000009663956,0.00003408184,0.00003027275,0.00002294676],"domain_scores_gemma":[0.9998685,0.00001115518,0.00006131279,0.00001045055,0.00001240339,0.00003619391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001330429,0.00001460557,0.0003883597,0.00002618241,0.000003737131,0.00003931067,0.000005863681,0.00003010038,0.9980526,0.00009712057,0.00006875494,0.001140442],"study_design_scores_gemma":[0.00005351928,0.0002127789,0.03024744,0.00002037299,0.00003570366,0.0008313514,0.00005432001,0.001068795,0.9574078,0.0001708799,0.009888645,0.000008336538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888275,0.002690459,0.003976577,0.0002710634,0.00007482547,0.00001926973,0.0009394777,0.0001658408,0.003035006],"genre_scores_gemma":[0.9876422,0.002048777,0.00236595,0.0001539771,0.00003748516,0.00004292288,0.001939029,0.00009723448,0.005672406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001749934,"threshold_uncertainty_score":0.00585413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01452820781599888,"score_gpt":0.258020831320553,"score_spread":0.2434926235045542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}