{"id":"W2098934646","doi":"10.2337/diabetes.54.2.482","title":"β-Cell <i>Pdx1</i> Expression Is Essential for the Glucoregulatory, Proliferative, and Cytoprotective Actions of Glucagon-Like Peptide-1","year":2005,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":243,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"","keywords":"PDX1; Endocrinology; Internal medicine; Proglucagon; Insulin; Islet; Amylin; Glucagon-like peptide-1; Glucagon; Biology; Glucagon-like peptide 1 receptor; Insulin oscillation; Alpha cell; Receptor; Chemistry; Agonist; Beta cell; Diabetes mellitus; Medicine; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001430539,0.0001561306,0.0002822288,0.00006705858,0.0001937672,0.00002042364,0.00005886459,0.0000842642,0.000127617],"category_scores_gemma":[0.0001070399,0.0001019608,0.0001140715,0.0001089549,0.0001707309,0.0001176605,0.0000343915,0.0001125363,0.000009717796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002497466,"about_ca_system_score_gemma":0.0000605478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006366432,"about_ca_topic_score_gemma":6.954205e-7,"domain_scores_codex":[0.9991113,0.00002905415,0.0002193381,0.0002420811,0.0001755954,0.0002226088],"domain_scores_gemma":[0.9990414,0.000339189,0.0001169719,0.0002572095,0.000151381,0.00009386912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001670593,0.0002395253,0.01162256,0.0001940734,0.0001500548,1.684139e-7,0.000780803,0.00001445771,0.9666796,0.0001144577,0.0162381,0.003799187],"study_design_scores_gemma":[0.001788558,0.0002508317,0.006563615,0.00009237813,0.0001978605,0.00000104374,0.0003352986,0.002302662,0.9698332,0.0001233503,0.01840151,0.0001097003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994047,0.001677786,0.0005593071,0.001057897,0.0001438373,0.0009969841,0.00004408083,0.00004508063,0.001427952],"genre_scores_gemma":[0.9951292,0.0000551888,0.001676807,0.0009028254,0.0002943581,0.0002956662,0.00001362933,0.00002140877,0.001610972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005058948,"threshold_uncertainty_score":0.415784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01452820781599888,"score_gpt":0.258020831320553,"score_spread":0.2434926235045542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}