{"id":"W2098940788","doi":"10.18433/j33892","title":"Co-Encapsulated CpG Oligodeoxynucleotides and Ovalbumin in PLGA Microparticles; An in vitro and in vivo Study","year":2014,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Asociación de Amigos de la Universidad de Navarra; Universidad de Navarra","keywords":"Ovalbumin; PLGA; Immunogenicity; CpG Oligodeoxynucleotide; Antigen; Chemistry; Immune system; In vivo; Antibody; CpG site; Molecular biology; In vitro; Nasal administration; Pharmacology; Immunology; Biology; Biochemistry; Biotechnology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.007490021,0.0003601763,0.0007298409,0.0007894075,0.0001938957,0.00009760681,0.0005579579,0.0001234608,0.0002357774],"category_scores_gemma":[0.0002883404,0.0003120609,0.00006192893,0.001021295,0.0009369657,0.001150804,0.0001212921,0.001434283,0.000009061024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001491258,"about_ca_system_score_gemma":0.0001214187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001435618,"about_ca_topic_score_gemma":0.0001569424,"domain_scores_codex":[0.9943211,0.002313597,0.001410182,0.0005833736,0.0005052555,0.000866477],"domain_scores_gemma":[0.9977555,0.0009973969,0.0003721925,0.0001282812,0.00009762315,0.0006490349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001468142,0.001166644,0.3847521,0.00003504128,0.00002581642,0.0002716201,0.001807425,0.001864088,0.5820161,0.00004424667,0.00003760251,0.02651123],"study_design_scores_gemma":[0.02254709,0.0009031541,0.05272989,0.0001100755,0.0001591555,0.000573408,0.003810186,0.2130309,0.6745884,0.0004801519,0.03026411,0.0008034768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960728,0.001738019,0.00002488819,0.0007541803,0.0004694274,0.0006137825,0.00001004327,0.00002175972,0.0002951506],"genre_scores_gemma":[0.997744,0.0006646154,0.0003134887,0.001051871,0.0001696832,0.00001968262,4.879212e-7,0.00002149952,0.00001472039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3320222,"threshold_uncertainty_score":0.9999331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1277439560325119,"score_gpt":0.4812775486503036,"score_spread":0.3535335926177917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}