{"id":"W2098940788","doi":"10.18433/j33892","title":"Co-Encapsulated CpG Oligodeoxynucleotides and Ovalbumin in PLGA Microparticles; An in vitro and in vivo Study","year":2014,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Asociación de Amigos de la Universidad de Navarra; Universidad de Navarra","keywords":"Ovalbumin; PLGA; Immunogenicity; CpG Oligodeoxynucleotide; Antigen; Chemistry; Immune system; In vivo; Antibody; CpG site; Molecular biology; In vitro; Nasal administration; Pharmacology; Immunology; Biology; Biochemistry; Biotechnology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002941161,0.0004127649,0.000314018,0.0001639336,0.00008390006,0.0001921646,0.0001616188,0.0004102355,0.0005326145],"category_scores_gemma":[0.0001597726,0.0001301371,0.0001976434,0.00008085168,0.0001780725,0.0002260743,0.0001376134,0.0003690265,0.0002890624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002005128,"about_ca_system_score_gemma":0.0001784545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003590134,"about_ca_topic_score_gemma":0.0003979459,"domain_scores_codex":[0.9997932,0.00004393054,0.00001288961,0.00005280148,0.00005761338,0.00003958059],"domain_scores_gemma":[0.9998893,0.00002654313,0.00003701386,0.000009621686,0.0000155035,0.00002198651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001361421,0.00006196547,0.00009135118,0.000067931,0.000005217048,0.00005144324,0.00001180139,0.00008544428,0.9984193,0.00002065174,0.00001511444,0.001033605],"study_design_scores_gemma":[0.00002279063,0.001997802,0.001068479,0.000008341106,0.00003308316,0.0001567653,0.00001125106,0.0008588844,0.9947897,0.00001149837,0.001038035,0.000003442334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992646,0.002469714,0.003985293,0.00005070698,0.00005177143,0.00005321845,0.000076846,0.00005047077,0.000615965],"genre_scores_gemma":[0.9929101,0.001185231,0.003342407,0.00005364265,0.00003501917,0.0000757125,0.0001415347,0.00001665983,0.00223964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005326145,"threshold_uncertainty_score":0.001781821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1277439560325119,"score_gpt":0.4812775486503036,"score_spread":0.3535335926177917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}