{"id":"W2098941747","doi":"10.1093/carcin/bgt240","title":"Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor","year":2013,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Curcumin; DNA damage; DNA repair; Histone; CHEK1; PARP inhibitor; Poly ADP ribose polymerase; Acetylation; G2-M DNA damage checkpoint; Cancer research; Biology; Chemistry; Molecular biology; Polymerase; Cell cycle checkpoint; Pharmacology; DNA; Biochemistry; Cell cycle; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002305312,0.0002649114,0.0002197759,0.00008578707,0.0001462511,0.00009207139,0.0001755074,0.0002056013,0.00007466421],"category_scores_gemma":[0.0005932928,0.0002577272,0.0001003023,0.0001148102,0.00008917963,0.000009956821,0.0003224604,0.00005805098,0.0001748024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000193177,"about_ca_system_score_gemma":0.0001102901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002076516,"about_ca_topic_score_gemma":0.00002991951,"domain_scores_codex":[0.9983735,0.0001996224,0.0002251042,0.0006207372,0.0001773539,0.0004036871],"domain_scores_gemma":[0.9987327,0.00006375438,0.00005377339,0.0006517756,0.0001794153,0.000318592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002853019,0.00004020924,0.002018532,0.00001997875,0.00002751488,0.00003798893,0.0002326709,0.000006040566,0.9921115,0.0000111253,0.003651023,0.001558113],"study_design_scores_gemma":[0.0005082275,0.0003903885,0.01960296,0.00001609022,0.00002541011,0.00005710371,0.0003634156,0.00006818999,0.9708927,0.00007085855,0.0076723,0.000332402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977449,0.0003937814,0.0003520726,0.0004866894,0.0001658612,0.000543444,0.00006649655,0.00005042855,0.0001963275],"genre_scores_gemma":[0.9961776,0.00001773399,0.001501423,0.0007781085,0.0001910015,0.0001374261,0.00004921256,0.00005930755,0.001088196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02121885,"threshold_uncertainty_score":0.9999875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418980975525247,"score_gpt":0.214337523325779,"score_spread":0.2001477135705266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}