{"id":"W2098941747","doi":"10.1093/carcin/bgt240","title":"Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor","year":2013,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Curcumin; DNA damage; DNA repair; Histone; CHEK1; PARP inhibitor; Poly ADP ribose polymerase; Acetylation; G2-M DNA damage checkpoint; Cancer research; Biology; Chemistry; Molecular biology; Polymerase; Cell cycle checkpoint; Pharmacology; DNA; Biochemistry; Cell cycle; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001048123,0.0004232099,0.0003548245,0.000486875,0.0001685876,0.0001862567,0.0001879393,0.0003171836,0.002828753],"category_scores_gemma":[0.00009801534,0.0001564578,0.0003904564,0.0001661118,0.0001296374,0.0002117773,0.0001766732,0.0005161589,0.00053572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002178155,"about_ca_system_score_gemma":0.0002124129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006966107,"about_ca_topic_score_gemma":0.001419277,"domain_scores_codex":[0.9999173,0.00001712484,0.000008722409,0.0000194581,0.00001857935,0.00001880617],"domain_scores_gemma":[0.9999133,0.00001454307,0.00001725043,0.00001695674,0.00001526094,0.00002267423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004734393,0.0001754742,0.0001804621,0.0003036317,0.00003960855,0.00008509974,0.00001219897,0.0001827091,0.9863811,0.0001022363,0.0003969705,0.01166715],"study_design_scores_gemma":[0.00008122346,0.001680512,0.004203064,0.00002133258,0.0000769789,0.0003972558,0.00001291138,0.000519936,0.9790183,0.00007642867,0.01390084,0.00001110789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.924186,0.04730047,0.009988496,0.001099643,0.0003669143,0.0002136526,0.001219955,0.0008721399,0.01475289],"genre_scores_gemma":[0.9760435,0.01079028,0.002268365,0.0001911375,0.00004277752,0.00007427981,0.000682926,0.00004243551,0.009864258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002828753,"threshold_uncertainty_score":0.009463072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418980975525247,"score_gpt":0.214337523325779,"score_spread":0.2001477135705266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}