{"id":"W2098947881","doi":"10.1002/bit.25193","title":"Purification of chimeric heavy chain monoclonal antibody EG2‐hFc using hydrophobic interaction membrane chromatography: An alternative to protein‐A affinity chromatography","year":2014,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Monoclonal antibody; Chemistry; Affinity chromatography; Chromatography; Elution; Antibody; Protein A; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002456891,0.0002464816,0.0004170024,0.0009317369,0.0001196481,0.00001678682,0.0001599406,0.0002620896,0.0000174423],"category_scores_gemma":[0.00003809116,0.0002167771,0.0001003588,0.0007751022,0.0002354314,0.0001221398,0.00009045631,0.0003661285,0.000005071569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002607445,"about_ca_system_score_gemma":0.00002578722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003604421,"about_ca_topic_score_gemma":0.000009825443,"domain_scores_codex":[0.9986299,0.00004951484,0.0003352898,0.0004178736,0.0002181388,0.0003492422],"domain_scores_gemma":[0.9992965,0.00003152332,0.0001107465,0.0003067111,0.00007576931,0.0001786909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002841017,0.0001569427,0.002640789,0.0002540796,0.0001325324,0.000008801441,0.00008498665,0.0001514554,0.9912052,0.001437733,0.000001831593,0.00364151],"study_design_scores_gemma":[0.0004998508,0.001181123,0.01324212,0.0002811679,0.0000446337,0.0001990166,0.00007757205,0.04929288,0.9340433,0.00007112868,0.0008229339,0.0002442544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918782,0.0003339647,0.006014818,0.0008829729,0.0001095825,0.0005475354,0.00001509279,0.0001634358,0.00005442154],"genre_scores_gemma":[0.9893003,0.0001905248,0.01023488,0.0000460701,0.0001235982,0.0000253684,0.00004267097,0.00002557006,0.00001101581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05716192,"threshold_uncertainty_score":0.8839912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02152915853470073,"score_gpt":0.3014541285281364,"score_spread":0.2799249699934356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}