{"id":"W2099029397","doi":"10.7164/antibiotics.57.326","title":"Hydrophobic Vancomycin Derivatives with Improved ADME Properties: Discovery of Telavancin (TD-6424)","year":2004,"lang":"en","type":"article","venue":"The Journal of Antibiotics","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"University of California, San Francisco","keywords":"ADME; Vancomycin; Chemistry; Pharmacology; Pharmacokinetics; Medicine; Biology; Staphylococcus aureus; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001374883,0.0003552357,0.0003141078,0.0001616161,0.00007878129,0.0003057944,0.0001840945,0.0003069361,0.0007779281],"category_scores_gemma":[0.0001846373,0.0001177987,0.0001547483,0.0001351728,0.0001690604,0.0002450132,0.0001835965,0.0004429165,0.0002064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002816879,"about_ca_system_score_gemma":0.0001848596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003412135,"about_ca_topic_score_gemma":0.0008997309,"domain_scores_codex":[0.9999102,0.00002172735,0.000008707097,0.00001557378,0.00002125312,0.00002255416],"domain_scores_gemma":[0.999885,0.000014835,0.00003490292,0.00000895436,0.00001591751,0.00004027931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001957132,0.00005447209,0.0002024972,0.00004466953,0.000006998995,0.0001929718,0.00001412814,0.0003574648,0.9916233,0.0001049923,0.00004041777,0.007162318],"study_design_scores_gemma":[0.0002590394,0.003517536,0.002155421,0.000008597481,0.0000436861,0.001061949,0.00002481667,0.00110693,0.9866924,0.00006157714,0.005051772,0.00001635828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937155,0.001981809,0.002490733,0.0001508707,0.00002088151,0.00007037403,0.0001761714,0.00005520693,0.00133862],"genre_scores_gemma":[0.9944289,0.000887557,0.003210132,0.00006206043,0.00001179937,0.00002311687,0.0002082021,0.00001262684,0.001155612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007779281,"threshold_uncertainty_score":0.002602458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01279303162551809,"score_gpt":0.2386568880944593,"score_spread":0.2258638564689412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}