{"id":"W2099036383","doi":"10.1042/bj3460063","title":"Activation of exocytosis by cross-linking of the IgE receptor is dependent on ADP-ribosylation factor 1-regulated phospholipase D in RBL-2H3 mast cells: evidence that the mechanism of activation is via regulation of phosphatidylinositol 4,5-bisphosphate synthesis","year":2000,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Institut Périmètre de physique théorique; Wellcome Trust","keywords":"Exocytosis; Phospholipase D; Phospholipase C; Phosphatidylinositol; Phosphatidic acid; Phosphatidylethanol; Cell biology; Secretion; Phospholipase; Mast cell; Biology; Cytosol; ADP ribosylation factor; Chemistry; Biochemistry; Signal transduction; Phospholipid; Enzyme; Golgi apparatus; Membrane; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003058515,0.0005719673,0.0004864355,0.0002042522,0.0001812195,0.0004782608,0.0002702972,0.0004255514,0.0008929784],"category_scores_gemma":[0.0001537145,0.0002177578,0.0006944484,0.0002012222,0.0002749678,0.0005095809,0.0003377045,0.0007156681,0.0005589081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005617699,"about_ca_system_score_gemma":0.0001591901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003271511,"about_ca_topic_score_gemma":0.0004210346,"domain_scores_codex":[0.9997551,0.00003917479,0.00004135524,0.00004641097,0.00006096238,0.00005693564],"domain_scores_gemma":[0.9998498,0.0000309902,0.00004242003,0.00003583241,0.00001217138,0.00002877859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001085249,0.000007563821,0.00008854298,0.00001293236,0.000002657753,0.00004953575,0.000004607429,0.00002376448,0.9993454,0.00002560214,0.000007953146,0.0003229275],"study_design_scores_gemma":[0.00003550555,0.0001267724,0.006224468,0.000002941435,0.0000134256,0.0003394358,0.000009628787,0.0008451288,0.9917027,0.00003802126,0.0006563132,0.000005572565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927592,0.001957731,0.003717328,0.0001700856,0.0000274726,0.00003378569,0.0005935548,0.000148147,0.0005927156],"genre_scores_gemma":[0.9945841,0.001054044,0.002606983,0.0000692756,0.00001730605,0.00005218082,0.0007257117,0.0000374503,0.0008529785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008929784,"threshold_uncertainty_score":0.004075944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01592823300596627,"score_gpt":0.2370363332430822,"score_spread":0.2211081002371159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}