{"id":"W2099036383","doi":"10.1042/bj3460063","title":"Activation of exocytosis by cross-linking of the IgE receptor is dependent on ADP-ribosylation factor 1-regulated phospholipase D in RBL-2H3 mast cells: evidence that the mechanism of activation is via regulation of phosphatidylinositol 4,5-bisphosphate synthesis","year":2000,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Institut Périmètre de physique théorique; Wellcome Trust","keywords":"Exocytosis; Phospholipase D; Phospholipase C; Phosphatidylinositol; Phosphatidic acid; Phosphatidylethanol; Cell biology; Secretion; Phospholipase; Mast cell; Biology; Cytosol; ADP ribosylation factor; Chemistry; Biochemistry; Signal transduction; Phospholipid; Enzyme; Golgi apparatus; Membrane; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003714368,0.0002101566,0.0002817219,0.00006187255,0.00008668676,0.00001732461,0.0003230927,0.000327087,0.0003785668],"category_scores_gemma":[0.00007525528,0.0001535548,0.000240577,0.0002534223,0.0001383918,0.00004244514,0.00002684712,0.0002053835,9.511978e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006882611,"about_ca_system_score_gemma":0.00006801252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007532295,"about_ca_topic_score_gemma":0.000002009018,"domain_scores_codex":[0.9980437,0.0001138998,0.0007748515,0.0002856207,0.000595201,0.0001866863],"domain_scores_gemma":[0.9981999,0.00008602261,0.00106639,0.0003629285,0.0002332483,0.00005148521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001121666,0.0001633955,0.006049928,0.00007357216,0.00005941106,9.731239e-8,0.0003961965,0.0002476627,0.9886729,0.00000874738,0.00005172722,0.003154754],"study_design_scores_gemma":[0.0005446609,0.0001129026,0.01335901,0.0006627556,0.00004533841,0.000002089651,0.00005770699,0.0006513267,0.9842761,0.00007280849,0.0000747478,0.0001405939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993842,0.0003287825,0.005121011,0.0001918651,0.00008390169,0.0003258727,0.00008939004,0.000003441939,0.00001374348],"genre_scores_gemma":[0.9989887,0.0005265133,0.0001478407,0.00004765384,0.00004627866,0.000008428143,0.0001511942,0.00002149788,0.00006189828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007309085,"threshold_uncertainty_score":0.6261784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01592823300596627,"score_gpt":0.2370363332430822,"score_spread":0.2211081002371159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}