{"id":"W2099045066","doi":"10.1128/jvi.02205-08","title":"Proteolytic Activation of the 1918 Influenza Virus Hemagglutinin","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":229,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Institutes of Health","keywords":"Proteases; Biology; Protease; NS2-3 protease; Virus; Trypsin; Virology; Influenza A virus; Orthomyxoviridae; Furin; Serine protease; Cleavage (geology); Tissue tropism; Tropism; Molecular biology; Viral replication; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001627851,0.000345984,0.0001665713,0.0001319431,0.0001384063,0.0002537622,0.0001572228,0.0002390367,0.001445657],"category_scores_gemma":[0.0002204911,0.000100538,0.0004980393,0.0001024017,0.00007991818,0.0002448605,0.0002253628,0.0004883885,0.0008807179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000188926,"about_ca_system_score_gemma":0.0001542021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004109112,"about_ca_topic_score_gemma":0.00047491,"domain_scores_codex":[0.9998099,0.0000397486,0.00002304038,0.00002752811,0.00004772353,0.00005212666],"domain_scores_gemma":[0.999909,0.00002244659,0.00001849141,0.0000157528,0.00001923206,0.00001507602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006294609,0.00001444928,0.000430278,0.00007610218,0.0000106994,0.0001302272,0.00001165799,0.00003363502,0.9976826,0.00008961574,0.00009734917,0.001360513],"study_design_scores_gemma":[0.00001034957,0.0001924178,0.01546058,0.00001453961,0.00002809069,0.00173872,0.00004082299,0.001600876,0.97288,0.0000801709,0.007945118,0.000008397772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771616,0.009797738,0.007172017,0.0002530011,0.0001663076,0.00006784652,0.001127756,0.00006248931,0.004191196],"genre_scores_gemma":[0.9833822,0.004132506,0.004972047,0.0001734372,0.00004510562,0.00002940896,0.0036535,0.00001597008,0.003595825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001445657,"threshold_uncertainty_score":0.004836202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06847493646919796,"score_gpt":0.3858429554248965,"score_spread":0.3173680189556986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}