{"id":"W2099059244","doi":"10.1096/fj.11-187682","title":"Enhanced Ca <sup>2+</sup> entry due to Orai1 plasma membrane insertion increases IL‐8 secretion by cystic fibrosis airways","year":2011,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Concordia University; Montreal Heart Institute; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal; Québec Science (Canada)","funders":"National Heart, Lung, and Blood Institute; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"ORAI1; STIM1; Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis; Endoplasmic reticulum; Cell biology; Secretion; Chemistry; ΔF508; Internal medicine; Endocrinology; Molecular biology; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004847077,0.0002426171,0.0002527208,0.0001417691,0.0007213125,0.000124881,0.0004569338,0.0001129603,0.00165526],"category_scores_gemma":[0.0005554762,0.0001598336,0.0001401561,0.0003585492,0.0001180547,0.0003882737,0.00009154416,0.0004330423,0.00051179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009643285,"about_ca_system_score_gemma":0.00007465992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001604843,"about_ca_topic_score_gemma":0.000006536321,"domain_scores_codex":[0.997829,0.0004673522,0.0004099979,0.0003142019,0.0005061374,0.0004733519],"domain_scores_gemma":[0.9989035,0.0002553469,0.0002190928,0.0002012473,0.00007865985,0.0003421675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004537885,0.0001354125,0.000009184416,0.0000141007,0.000008149288,0.00002610303,0.003557877,0.001869113,0.9890226,0.00005620572,0.003482003,0.001365534],"study_design_scores_gemma":[0.0005436544,0.0003784019,0.00004670331,0.0001048951,0.00003295676,0.0004929484,0.0008576594,0.005347251,0.9910187,0.0001402236,0.0008119384,0.0002247233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943048,0.00003342085,0.003054083,0.0003718343,0.0006592902,0.0002436398,0.00008840688,0.00006495527,0.001179515],"genre_scores_gemma":[0.9977114,0.0002324401,0.0001358178,0.0006851702,0.0004391304,0.00001728578,0.00001036334,0.00003218517,0.0007361913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003478138,"threshold_uncertainty_score":0.9992574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0200726152230966,"score_gpt":0.22403558547099,"score_spread":0.2039629702478934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}