{"id":"W2099059244","doi":"10.1096/fj.11-187682","title":"Enhanced Ca <sup>2+</sup> entry due to Orai1 plasma membrane insertion increases IL‐8 secretion by cystic fibrosis airways","year":2011,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Concordia University; Montreal Heart Institute; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal; Québec Science (Canada)","funders":"National Heart, Lung, and Blood Institute; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"ORAI1; STIM1; Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis; Endoplasmic reticulum; Cell biology; Secretion; Chemistry; ΔF508; Internal medicine; Endocrinology; Molecular biology; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001872756,0.0002810289,0.0003237271,0.0001657304,0.0001282005,0.0003820118,0.0001407076,0.000427843,0.001835971],"category_scores_gemma":[0.0001752152,0.0001427154,0.0003482517,0.0001395799,0.0003051397,0.0003267901,0.0002321072,0.0007430224,0.0004461074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002726595,"about_ca_system_score_gemma":0.0001273251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004347656,"about_ca_topic_score_gemma":0.0002805959,"domain_scores_codex":[0.9997744,0.00003872128,0.00002157257,0.00003928644,0.00006058527,0.00006545933],"domain_scores_gemma":[0.9998277,0.00004442873,0.00003790938,0.00002300373,0.00002358744,0.00004326416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001079434,0.000008635119,0.0001588483,0.0000181135,0.000002012421,0.0000455697,0.000007535967,0.000009401839,0.9994154,0.00001197113,0.00001895713,0.0001955277],"study_design_scores_gemma":[0.00003873897,0.0004713734,0.02329798,0.000008871173,0.00002095746,0.0004645259,0.00009207198,0.001014167,0.9736266,0.00004194534,0.0009172663,0.00000546164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975299,0.0008532873,0.0006828053,0.0001282494,0.0000296479,0.00001215129,0.0002065568,0.0000432431,0.0005141661],"genre_scores_gemma":[0.9983314,0.0002672942,0.0004674889,0.0000695425,0.00001412547,0.0000165374,0.0001799021,0.00001010765,0.0006436206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001835971,"threshold_uncertainty_score":0.006141961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0200726152230966,"score_gpt":0.22403558547099,"score_spread":0.2039629702478934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}