{"id":"W2099065464","doi":"10.1017/s0031182005007328","title":"Resistance mechanism development to the topoisomerase-I inhibitor Hoechst 33342 by<i>Leishmania donovani</i>","year":2005,"lang":"en","type":"article","venue":"Parasitology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University Health Centre","funders":"","keywords":"Biology; Leishmania donovani; Topoisomerase; Leishmania; Transporter; Gene; Kinetoplastida; Drug resistance; Mutation; Cell biology; In vitro; Biochemistry; Genetics; Parasite hosting; Leishmaniasis; Visceral leishmaniasis; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005031162,0.0003113615,0.0005433109,0.0001516925,0.0004787076,0.00004127438,0.0003992332,0.0001452744,0.0001896639],"category_scores_gemma":[0.0003037562,0.0002235898,0.00008777257,0.0003951797,0.0001427522,0.00009579761,0.0002360168,0.000417207,0.002629848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000324751,"about_ca_system_score_gemma":0.0001846268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003251712,"about_ca_topic_score_gemma":0.001360997,"domain_scores_codex":[0.9973088,0.000135405,0.0005195603,0.000620439,0.0005705222,0.000845271],"domain_scores_gemma":[0.998526,0.0002132022,0.0001012341,0.0006525033,0.0002084958,0.000298569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000979766,0.0006045858,0.01196519,0.000116662,0.0004682255,0.0002199834,0.002401797,0.000005954679,0.05704052,0.007877615,0.8976496,0.02067004],"study_design_scores_gemma":[0.001010898,0.0001577005,0.01719321,0.00004600712,0.00003549309,0.0001097147,0.0002198539,0.000007123336,0.08248486,0.000120795,0.8983546,0.0002596989],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8335599,0.002953641,0.00182181,0.1371944,0.0005455888,0.001694148,0.00002756766,0.000243402,0.02195959],"genre_scores_gemma":[0.9691551,0.0002208789,0.009145329,0.009101694,0.0006472262,0.0004169946,0.00002672584,0.0000543862,0.0112317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1355952,"threshold_uncertainty_score":0.9981467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01833570164671585,"score_gpt":0.3172496513470491,"score_spread":0.2989139497003333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}