{"id":"W2099067049","doi":"10.1677/joe-09-0068","title":"Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic β cells","year":2009,"lang":"en","type":"article","venue":"Journal of Endocrinology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital; University of New Brunswick; Canada Research Chairs","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; University of Toronto","keywords":"Hyperpolarization (physics); Internal medicine; Endocrinology; Membrane potential; Potassium channel; Extracellular; Secretion; Patch clamp; Inward-rectifier potassium ion channel; Biology; Chemistry; Cell biology; Biophysics; Ion channel; Electrophysiology; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002165653,0.0002774095,0.0002138396,0.0001706967,0.0001183009,0.0002610372,0.0001403803,0.0002605501,0.0005756525],"category_scores_gemma":[0.0001950429,0.0000814748,0.0002489798,0.000143386,0.0001601077,0.000257041,0.0001366118,0.0004097891,0.0002380414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001834544,"about_ca_system_score_gemma":0.0001841526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005292274,"about_ca_topic_score_gemma":0.0004184206,"domain_scores_codex":[0.9998933,0.00001308546,0.00001398234,0.00003077895,0.00002907999,0.00001980216],"domain_scores_gemma":[0.9998454,0.00002230905,0.00003585246,0.00002358032,0.00003321918,0.00003960471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002661939,0.000004159547,0.0001180353,0.00001386175,0.000001637364,0.00001494232,0.000006783488,0.00001312272,0.9994585,0.00001605766,0.000004479932,0.0003218405],"study_design_scores_gemma":[0.00001550903,0.0003377664,0.02258909,0.00001110352,0.00003662248,0.0006634031,0.0000781121,0.0009374908,0.9724696,0.00007880331,0.002771643,0.00001078367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912211,0.002598473,0.00441709,0.0001003494,0.00002422651,0.0000249769,0.0005539981,0.00003504282,0.001024681],"genre_scores_gemma":[0.9859316,0.002828822,0.006803404,0.0001663628,0.00002956776,0.00008346053,0.002113865,0.00003235741,0.002010535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005756525,"threshold_uncertainty_score":0.001925766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01258628112556629,"score_gpt":0.2305349734848275,"score_spread":0.2179486923592612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}