{"id":"W2099108621","doi":"10.1016/s0140-6736(14)60153-7","title":"Oral 9-cis retinoid for childhood blindness due to Leber congenital amaurosis caused by RPE65 or LRAT mutations: an open-label phase 1b trial","year":2014,"lang":"en","type":"article","venue":"The Lancet","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital","funders":"Canadian Institutes of Health Research","keywords":"RPE65; Medicine; Visual acuity; Cis-trans-Isomerases; Ophthalmology; Retinal; Pediatrics; Retinal pigment epithelium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001670678,0.002843886,0.004321636,0.0004769872,0.0005573019,0.001611957,0.001225932,0.003150614,0.008560771],"category_scores_gemma":[0.001381973,0.0008248797,0.003741243,0.0005431465,0.001216583,0.001440751,0.0003984394,0.005813289,0.001782051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001420752,"about_ca_system_score_gemma":0.001499319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002876058,"about_ca_topic_score_gemma":0.006431758,"domain_scores_codex":[0.9994376,0.0002095449,0.00003112069,0.0001005907,0.00005451412,0.0001665218],"domain_scores_gemma":[0.9992393,0.0002345527,0.0001219244,0.0000543309,0.00006496278,0.0002849531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9002972,0.006481242,0.0009690775,0.002418911,0.003262568,0.0002457997,0.0001346702,0.0008934783,0.006151747,0.0006643237,0.008463712,0.07001721],"study_design_scores_gemma":[0.9615264,0.03398924,0.0009238516,0.0001037586,0.0005371464,0.0001016587,0.00003322065,0.0002506102,0.0003819795,0.0002892842,0.001843164,0.00001978926],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9099409,0.05494991,0.003447113,0.005954334,0.003293311,0.005445088,0.006492844,0.0006852475,0.009791176],"genre_scores_gemma":[0.9350803,0.02831439,0.003743556,0.006986049,0.001144014,0.005793846,0.00521904,0.0001391746,0.01357971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008560771,"threshold_uncertainty_score":0.02863866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05113970424309294,"score_gpt":0.3491334326080065,"score_spread":0.2979937283649136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}