{"id":"W2099139140","doi":"10.1196/annals.1329.034","title":"Blockade by SB203580 of <i>Cyp1a1</i> Induction by 2,3,7,8‐Tetrachlorodibenzo‐<i>p</i>‐dioxin, and the Possible Mechanism: Possible Involvement of the p38 Mitogen‐Activated Protein Kinase Pathway in Shuttling of Ah Receptor Overexpressed in COS‐7 Cells","year":2004,"lang":"en","type":"article","venue":"Annals of the New York Academy of Sciences","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Aryl hydrocarbon receptor; p38 mitogen-activated protein kinases; Aryl hydrocarbon receptor nuclear translocator; Nucleus; Protein kinase A; Chemistry; Kinase; Molecular biology; Cytoplasm; Reporter gene; Chromosomal translocation; Cell biology; Mitogen-activated protein kinase; Signal transduction; Transcription factor; Gene; Biology; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001978074,0.0004899372,0.0003437816,0.0001834376,0.0001752843,0.0002613724,0.000245063,0.0002787973,0.001468192],"category_scores_gemma":[0.0001148163,0.00014446,0.0002597371,0.0001757732,0.0002860948,0.0001845798,0.000137096,0.0006502316,0.0006231379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003437303,"about_ca_system_score_gemma":0.000344396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000745501,"about_ca_topic_score_gemma":0.001145133,"domain_scores_codex":[0.9998542,0.00002984556,0.00001855455,0.00002272636,0.00003090284,0.00004373795],"domain_scores_gemma":[0.9999143,0.00002407624,0.00001766262,0.00001099204,0.00001140509,0.00002149756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001522419,0.00004952526,0.00004323858,0.00003057099,0.000002723029,0.00004013252,0.00000741499,0.00002265707,0.9989793,0.00009278435,0.00003883617,0.0005406418],"study_design_scores_gemma":[0.00002462547,0.000282318,0.001115784,0.000002336411,0.000005996661,0.0001022291,0.00001177387,0.000366256,0.9969126,0.00002635388,0.001147993,0.000001779425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924678,0.001737277,0.002497853,0.0003177247,0.0001104581,0.00003922694,0.0003189208,0.0001677018,0.002343051],"genre_scores_gemma":[0.9890731,0.001906362,0.003689243,0.0001162329,0.00004791541,0.0000923866,0.00091277,0.00003286345,0.004129259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001468192,"threshold_uncertainty_score":0.004911542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02594307771711639,"score_gpt":0.2489943780444104,"score_spread":0.223051300327294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}