{"id":"W2099160484","doi":"10.1002/chem.200701775","title":"Concise Enantioselective Total Syntheses of (+)‐Homochelidonine, (+)‐Chelamidine, (+)‐Chelidonine, (+)‐Chelamine and (+)‐Norchelidonine by a Pd<sup>II</sup>‐Catalyzed Ring‐Opening Strategy","year":2008,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Enantioselective synthesis; Phenanthridine; Epoxide; Regioselectivity; Alkene; Stereochemistry; Total synthesis; Chemistry; Ring (chemistry); Aryl; Medicinal chemistry; Combinatorial chemistry; Catalysis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001692327,0.0005651251,0.0004220739,0.0001869566,0.0001816034,0.0002667911,0.0004513859,0.0002476934,0.001386945],"category_scores_gemma":[0.0001053589,0.0001704913,0.0002377291,0.0002217654,0.0001618568,0.0003570792,0.0004513016,0.000521227,0.000965266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002227355,"about_ca_system_score_gemma":0.0004314962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003994415,"about_ca_topic_score_gemma":0.0009261474,"domain_scores_codex":[0.9998558,0.00001946955,0.00002000239,0.00002804695,0.00003761471,0.00003898307],"domain_scores_gemma":[0.9999377,0.000006616217,0.00001530786,0.0000100293,0.00001466348,0.00001578439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001461606,0.00009501792,0.0001963485,0.0003350167,0.00003415534,0.0004779171,0.0001220712,0.0009553954,0.9659373,0.001424728,0.0005423811,0.02973347],"study_design_scores_gemma":[0.00005292834,0.0005114442,0.0007301067,0.00001270034,0.00003389915,0.0007318523,0.0000464239,0.0010757,0.9832929,0.0002626634,0.01322894,0.00002045077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8498278,0.007628664,0.08689766,0.0003383017,0.0002328906,0.0005195648,0.002078026,0.000791205,0.05168593],"genre_scores_gemma":[0.9408633,0.005289174,0.0413109,0.0001380453,0.00004417076,0.0001675703,0.0009205434,0.00008901475,0.01117728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001386945,"threshold_uncertainty_score":0.004639804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02392784015324695,"score_gpt":0.2570096360903673,"score_spread":0.2330817959371203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}