{"id":"W2099160484","doi":"10.1002/chem.200701775","title":"Concise Enantioselective Total Syntheses of (+)‐Homochelidonine, (+)‐Chelamidine, (+)‐Chelidonine, (+)‐Chelamine and (+)‐Norchelidonine by a Pd<sup>II</sup>‐Catalyzed Ring‐Opening Strategy","year":2008,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Enantioselective synthesis; Phenanthridine; Epoxide; Regioselectivity; Alkene; Stereochemistry; Total synthesis; Chemistry; Ring (chemistry); Aryl; Medicinal chemistry; Combinatorial chemistry; Catalysis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001471833,0.0009049786,0.001429875,0.0002758981,0.0008484955,0.000143626,0.0006053756,0.0002365071,0.001091864],"category_scores_gemma":[0.001790711,0.0007988716,0.0004696563,0.0008758354,0.001045493,0.0004884832,0.0005646673,0.002301427,0.00005992102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000200531,"about_ca_system_score_gemma":0.0006867879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004992815,"about_ca_topic_score_gemma":6.456777e-7,"domain_scores_codex":[0.9946257,0.0003627433,0.001617534,0.001017757,0.001072045,0.00130416],"domain_scores_gemma":[0.9959542,0.0003493091,0.0007129145,0.0007595876,0.001018339,0.001205694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001321913,0.0008607187,0.003118811,0.0006600358,0.000765271,0.00309959,0.001379771,0.0001334914,0.970685,0.00001078546,0.008837052,0.009127534],"study_design_scores_gemma":[0.01630893,0.002756606,0.00895269,0.002867911,0.0007551914,0.08542663,0.002565335,0.008161365,0.8590848,0.00002658342,0.01094225,0.002151643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722351,0.005308288,0.0002832568,0.0005922203,0.00005067252,0.0004302601,0.0001240952,0.0001415986,0.02083451],"genre_scores_gemma":[0.9781078,0.003075218,0.001268326,0.0001005822,0.0008783674,0.00001716349,0.0001549086,0.0002213092,0.01617636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1116002,"threshold_uncertainty_score":0.9998685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02392784015324695,"score_gpt":0.2570096360903673,"score_spread":0.2330817959371203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}